9 documents found, page 1 of 1
Impact of a daily legume-based meal on blood and anthropometric parameters in a...
Ferreira, H; Vasconcelos, M; Gil, AM; Silveira, J; Alves, P; Martins, S; Assunção, M; Guimarães, JT; Pinto, EThis pilot study aimed to assess the impact of substituting a traditional lunch for a vegetarian legume-based meal on blood and anthropometric parameters in a group of omnivorous adults. A one-group comparison, quasi-experimental dietary intervention was designed. A vegetarian legume-based meal was offered for 8 consecutive weeks (weekdays) to non-vegetarian individuals (n = 26), (28 years [P25 = 20.0, P75 = 35...
Urine Metabolomics during a Legume Diet Intervention Suggests Altered Metabolic...
Ferreira, H; Duarte, D; Rodrigues, JA; Vasconcelos, MW; Pinto, E; Gil, AMGiven the general increase in legume consumption worldwide, there is a need to characterize the resulting human metabolic adaptations in order to demonstrate potential legume diet/health relationships. A nuclear magnetic resonance (NMR) metabolomics urine study was carried out on a small cohort (n = 18) to characterize the excretory effects of a pilot longitudinal 8-week legume-based dietary intervention. Despi...
Impact of a legumes diet on the human gut microbiome articulated with fecal and...
Ferreira, H; Duarte, D; Carneiro, TJ; Costa, C; Barbosa, JC; Rodrigues, JE; Alves, P; Vasconcelos, M; Pinto, E; Gomes, A; Gil, AMBackground & aims: Legumes intake is known to be associated with several health benefits the origins of which is still a matter of debate. This paper addresses a pilot small cohort to probe for metabolic aspects of the interplay between legumes intake, human metabolism and gut microbiota. Methods: Untargeted nuclear magnetic resonance (NMR) metabolomics of blood plasma and fecal extracts was carried out, in tan...
Impact of a daily legume-based meal on dietary and nutritional intake in a grou...
Ferreira, H; Vasconcelos, M; Gil, AM; Oliveira, B; Varandas, E; Vilela, E; Say, K; Silveira, J; Pinto, EAdopting eco-friendly diets will demand the consumption of more plant-based protein food sources such as legumes. However, assessing the impact of such a dietary shift on the dietary and nutritional intake of traditionally omnivorous populations is needed. The objective of this study was to assess the impact of substituting a traditional omnivorous-based lunch for a vegetarian, legume-based meal on the daily di...
Potential role of pulses in the development of functional foods modulating infl...
Ferreira, H; Pinto, E; Vasconcelos, MW; Gil, AMInflammation and oxidative stress-related metabolic disorders are on the genesis of several highly prevalent noncommunicable diseases, including cardiovascular diseases, which currently represent the leading cause of premature death worldwide. However, evidence suggests that healthy dietary habits may exert positive antiinflammatory and antioxidant effects by preventing the onset or modulating such chronic cond...
Benefits of pulse consumption on metabolism and health: A systematic review of ...
Ferreira, H; Vasconcelos, M; Gil, AM; Pinto, EPulses are nutrient-dense foods that have for a long time been empirically known to have beneficial effects in human health. In the last decade, several studies have gathered evidence of the metabolic benefits of pulse intake. However, it remains unclear at what amounts these effects may be attained. This study aimed to systematically review the scientific outputs of the last two decades regarding health benefi...
Newborn Urinary Metabolic Signatures of Prematurity and Other Disorders: A Case...
Diaz, SO; Pinto, JJ; Barros, AS; Morais, E; Duarte, D; Negrão, F; Pita, C; Almeida, MC; Carreira, IM; Spraul, M; Gil, AMThis work assesses the urinary metabolite signature of prematurity in newborns by nuclear magnetic resonance (NMR) spectroscopy, while establishing the role of possible confounders and signature specificity, through comparison to other disorders. Gender and delivery mode are shown to impact importantly on newborn urine composition, their analysis pointing out at specific metabolite variations requiring consider...
Fibrinogen scaffolds with immunomodulatory properties promote in vivo bone rege...
Vasconcelos, DM; Gonçalves, RM; Almeida, CR; Pereira, IO; Oliveira, MI; Neves, N; Silva, AM; Ribeiro, AC; Cunha, C; Almeida, AR; Ribeiro, CC; Gil, AMThe hypothesis behind this work is that fibrinogen (Fg), classically considered a pro-inflammatory protein, can promote bone repair/regeneration. Injury and biomaterial implantation naturally lead to an inflammatory response, which should be under control, but not necessarily minimized. Herein, porous scaffolds entirely constituted of Fg (Fg-3D) were implanted in a femoral rat bone defect and investigated at tw...
NMR metabolomics of human lung tumours reveals distinct metabolic signatures fo...
Rocha, CM; Barros, AS; Goodfellow, BJ; Carreira, IM; Gomes, AA; Sousa, V; Bernardo, J; Carvalho, L; Gil, AM; Duarte, IFLung tumour subtyping, particularly the distinction between adenocarcinoma (AdC) and squamous cell carcinoma (SqCC), is a critical diagnostic requirement. In this work, the metabolic signatures of lung carcinomas were investigated through (1)H NMR metabolomics, with a view to provide additional criteria for improved diagnosis and treatment planning. High Resolution Magic Angle Spinning Nuclear Magnetic Resonanc...