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Devices used for photobiomodulation of the brain-a comprehensive and systematic...

Fernandes, Filipa; Oliveira, Sofia; Monteiro, Francisca; Gasik, Michael; Silva, Filipe Samuel; Sousa, Nuno; Carvalho, Óscar; Catarino, Susana Oliveira

A systematic review was conducted to determine the trends in devices and parameters used for brain photobiomodulation (PBM). The revised studies included clinical and cadaveric approaches, in which light stimuli were applied to the head and/or neck. PubMed, Scopus, Web of Science and Google Scholar databases were used for the systematic search. A total of 2133 records were screened, from which 97 were included ...


3D Multi-Material Laser Powder Bed Fusion of 420 stainless steel-Cu parts for P...

Cunha, Ângela Sofia Varela; Marques, Ana Cristina Ribeiro; Silva, Filipe Samuel; Carvalho, Óscar Samuel Novais; Bartolomeu, Flávio; Gasik, Michael

Plastic injection molding is one of the fastest-growing industries in the world. However, although it presents numerous advantages, the costs associated with the mold and machine are high and, therefore, this process is only profitable for mass production. Moreover, the reduction in the cycle time, more specifically the cooling time, has been a never-ending challenge since it has a direct influence on productio...


MSC morphofunctional programming for improved orthopaedic implantation outcomes

Fonseca, Francisca Rocha Melo; Pinto, Inês Mendes; Gasik, Michael; Silva, Filipe Samuel; Miranda, Maria Georgina Macedo

Orthopaedic interventions have risen over the last two decades and are expected to increase due to aging population. Despite advances in orthopaedic implant research, prosthetic failure is often observed, leading to implant replacement. Impaired implant fixation is mainly due to an improper mechanical stimulation at the interface between natural bone and the implant, often composed of Ti6Al4V. At the cellular l...


Bio-piezoelectric ceramic composites for electroactive implants—biological perf...

Fernandes, Beatriz Ferreira; Silva, Neusa; Marques, Joana Faria; Da Cruz, Mariana Brito; Tiainen, Laura Katariina; Gasik, Michael

Barium titanate (BaTiO<sub>3</sub>) piezoelectric ceramic may be a potential alternative for promoting osseointegration due to its piezoelectric properties similar to bone electric potentials generated in loading function. In this sense, the aim of this in vitro study was to evaluate the cellular response of human osteoblasts and gingival fibroblasts as well as the impact on <i>S. oralis</i> when in contact wit...


Innovative 3D-printed osteogenic-stimulating structures for orthopaedic implants

Dias, Juliana Marques; Silva, Filipe Samuel; Gasik, Michael; Bartolomeu, Flávio; Miranda, Maria Georgina Macedo

[Excerpt] According to The Lancet, "Total hip arthroplasty is the surgery of the century". In the upcoming decades, approximately 10 million total hip and knee arthroplasties (THA and TKA) are expected annually, aiming to restore complete joint functionality and enable pain-free mobility. However, more than 20% of the existing implant solutions induce severe bone resorption, ultimately requiring revision surger...


Improving the interface between orthopaedic implants and bone - a comparison be...

Fonseca, Francisca Rocha Melo; Gasik, Michael; Pinto, Inês Mendes; Madeira, Sara Cristina Soares; Silva, Filipe Samuel; Miranda, Maria Georgina Macedo

Orthopedic implants for load-bearing applications are usually composed of titanium-based materials. However, insufficient bioactivity of metallic materials impairs the bonding with bone, compromising osseointegration at an early stage. The implant-bone interface may be improved by regulating some surface properties of the biomaterials, including surface chemical composition, surface energy, roughness and topogr...


Mechanical properties of Ti6Al4V fabricated by laser powder bed fusion: a revie...

Bartolomeu, Flávio; Gasik, Michael; Silva, Filipe Samuel; Miranda, Maria Georgina Macedo

Ti6Al4V alloy is an ideal lightweight structural metal for a huge variety of engineering applications due to its distinguishing combination of high specific mechanical properties, excellent corrosion resistance and biocompatibility. In this review, the mechanical properties of selective laser-melted Ti6Al4V parts are addressed in detail, as well as the main processing and microstructural parameters that influen...


Multi-functional Inconel 718 - Pure Copper parts fabricated by 3D multi-materia...

Marques, Ana Cristina Ribeiro; Cunha, Ângela Sofia Varela; Gasik, Michael; Carvalho, Óscar Samuel Novais; Silva, Filipe Samuel; Bartolomeu, Flávio

Currently, most aerospace components are under extreme operating conditions such as high fluid pressure, mechanical loads, and thermal stresses [1,2]. The structural integrity of the component is assured by the use of high strength and temperature resistant materials as well distinct cooling mechanisms [1,2]. Inconel 718 (Inc718) is usually used in aerospace components (e.g rocket engines) due to their resistan...


3D Multi-Material Laser Powder Bed Fusion: an innovative 420 stainless steel-Cu...

Cunha, Ângela Sofia Varela; Marques, Ana Cristina Ribeiro; Silva, Filipe Samuel; Gasik, Michael; Trindade, Bruno; Carvalho, Óscar Samuel Novais

The plastic injection molding industry is one of the fastest-growing industries in the world since it produces a huge amount of plastic-based components of various types and sizes for the electronics, automotive, pharmaceutical, and aerospace industries [1,2]. However, although it presents numerous advantages (high dimensional and geometric precision, repeatability, and adaptability to a wide range of materials...


Mechanical properties of Ti6Al4V fabricated by laser powder bed fusion: a revie...

Bartolomeu, Flávio; Gasik, Michael; Silva, Filipe Samuel; Miranda, Georgina

Ti6Al4V alloy is an ideal lightweight structural metal for a huge variety of engineering applications due to its distinguishing combination of high specific mechanical properties, excellent corrosion resistance and biocompatibility. In this review, the mechanical properties of selective laser-melted Ti6Al4V parts are addressed in detail, as well as the main processing and microstructural parameters that influen...


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