16 documents found, page 1 of 2

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Microencapsulation of the Biocide Benzisothiazolinone (BIT) by Inclusion in Met...

Silva, Vânia F. M.; Silva, Aurora; Garrido, Ermelinda M. P. J.; Borges, Fernanda; Gaspar, Alexandra; Garrido, Jorge P. M. J.; Garrido, E. Manuela

The excessive use of biocides has considerable environmental and economic impacts; this is why new technologies have been sought to decrease the concentration levels applied in an effort to reduce the use of these substances. Microencapsulation using cyclodextrins has been widely used in the food and pharmaceutical industries as a way of reducing the concentrations of the active substance necessary to achieve a...


Biological and Medicinal Properties of Natural Chromones and Chromanones

Gaspar, Alexandra; Garrido, E. Manuela P. J.; Borges, Fernanda; Garrido, Jorge M. P. J.

Emerging threats to human health require a concerted effort to search for new treatment therapies. One of the biggest challenges is finding medicines with few or no side effects. Natural products have historically contributed to major advances in the field of pharmacotherapy, as they offer special characteristics compared to conventional synthetic molecules. Interest in natural products is being revitalized, in...


Calcified Pleural Plaques due to Exposure to Asbestos

Rodrigues, Mário; Monteiro, Manuel; Salvado, Vera; Gaspar, Alexandra


The synthesis, crystal structure and Hirshfeld analysis of 4-(3,4-dimethylanili...

Gomes, Lígia Rebelo; Low, John Nicolson; Borges, Fernanda; Gaspar, Alexandra; Mesiti, Francesco

The structure of the title quinoline carboxamide derivative, C26H25N3O, is described. The quinoline moiety is not planar as a result of a slight puckering of the pyridine ring. The secondary amine has a slightly pyramidal geometry, certainly not planar. Both intra- and intermolecular hydrogen bonds are present. Hirshfeld surface analysis and lattice energies were used to investigate the intermolecular interacti...


Crystal structures of ethyl 6-(4-methylphenyl)-4-oxo-4H-chromene-2-carboxylate ...

Gomes, Ligia R.; Low, John Nicolson; Fernandes, Carlos; Gaspar, Alexandra; Borges, Fernanda

The crystal structures of two chromone derivatives, viz. ethyl 6-(4-methyl­phen­yl)-4-oxo-4H-chromene-2-carboxyl­ate, C19H16O4, (1), and ethyl 6-(4-fluoro­phen­yl)-4-oxo-4H-chromene-2-carboxyl­ate C18H13FO4, (2), have been determined: (1) crystallizes with two mol­ecules in the asymmetric unit. A comparison of the dihedral angles beween the mean planes of the central chromone core with those of the substituents...


Plummer-Vinson Syndrome

Alcatrão, Mário J.; Gaspar, Alexandra; Neves, Cláudia; Bravo, Ana


A comparison of the structures of some 2- and 3-substituted chromone derivative...

Gomes, Ligia R.; Low, John Nicolson; Cagide, Fernando; Gaspar, Alexandra; Borges, Fernanda

The crystal structures of the 3-substituted tertiary chromone carboxamide derivative, C17H13NO3, N-methyl-4-oxo-N-phenyl-4H-chromene-3-carboxamide (1), and the chromone carbonyl pyrrolidine derivatives, C14H13NO3, 3-(pyrrolidine-1-carbon­yl)-4H-chromen-4-one (3) and 2-(pyrrolidine-1-carbon­yl)-4H-chromen-4-one (4) have been determined. Their structural features are discussed and compared with similar compounds ...


Chromone: A valid scaffold in medicinal chemistry

Gaspar, Alexandra; Matos, Maria João; Garrido, Jorge; Uriarte, Eugénio; Borges, Fernanda

Chromones are a group of naturally occurring compounds that are ubiquitous in nature, especially in plants. The word chromone is derived from the Greek word chroma, meaning “color”, which point out that many chromone derivatives can exhibit a diversity of colors.


Influence of Hydroxypropyl- β -Cyclodextrin on the Photostability of Fungicide ...

Fernandes, Carlos; Encarnação, Igor; Gaspar, Alexandra; Garrido, Jorge; Borges, Fernanda; Garrido, E. Manuela

Pesticides continue to play an important role in pest management. However, the intensive pesticide application has triggered several environment negative effects that cannot be disregarded. In this study, the inclusion complex of pyrimethanil with HP- β -CD has been prepared and characterized by proton nuclear magnetic resonance spectroscopy. The formation of the pyrimethanil/HP- β -CD inclusion complex increas...


Hydroxycinnamic acid antioxidants: an electrochemical overview

Teixeira, José; Gaspar, Alexandra; Garrido, E. Manuela; Garrido, Jorge; Borges, Fernanda

Hydroxycinnamic acids (such as ferulic, caffeic, sinapic, and p-coumaric acids) are a group of compounds highly abundant in food that may account for about one-third of the phenolic compounds in our diet. Hydroxycinnamic acids have gained an increasing interest in health because they are known to be potent antioxidants. These compounds have been described as chain-breaking antioxidants acting through radical sc...


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