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Genome-wide association study identifies genetic variants underlying footrot in...

Gaspar, Daniel; Ginja, Catarina; Carolino, Nuno; Leão, Célia; Monteiro, Helena; Tábuas, Lino; Branco, Sandra; Padre, Ludovina; Caetano, Pedro

Ovine footrot caused by Dichelobacter nodosus (D. nodosus) is a contagious disease with serious economic and welfare impacts in sheep production systems worldwide. A better understanding of the host genetic architecture regarding footrot resistance/susceptibility is crucial to develop disease control strategies that efficiently reduce infection and its severity. A genome-wide association study was performed usi...


Genome-wide association study identifies genetic variants underlying footrot in...

Gaspar, Daniel; Ginja, Catarina; Carolino, Nuno; Leão, Célia; Monteiro, Helena; Tábuas, Lino; Branco, Sandra; Padre, Ludovina; Caetano, Pedro

This is the first attempt to identify molecular markers associated with footrot in Portuguese Merino sheep. These findings provide relevant information on a likely genetic association underlying footrot resistance/susceptibility and the potential candidate genes affecting this trait. Genetic selection strategies assisted on the information obtained from this study could enhance Merino sheep-breeding programs, i...


A metagenomics approach to characterize the footrot microbiome in Merino sheep

Usié, Ana; Leão, Célia; Gaspar, Daniel; Monteiro, Helena; Tábuas, Lino; Bettencourt, Elisa; Caetano, Pedro; Padre, Ludovina; Carolino, Nuno

In the Portuguese Alentejo region, Merino sheep breed is the most common breed, reared for the production of meat, dairy, and wool. Footrot is responsible for lameness, decreased animal welfare, and higher production losses, generating a negative economic impact. The disease is caused by Dichelobacter nodosus that interacts with the sheep foot microbiome, to date largely uncharacterized. In fact, Dichelobacter ...


A Simulation of Data Censored Rigth Type I with Weibull Distribution

Gaspar, Daniel; Andrande Ferreira, Luis

In the maintenance and reliability field, there are frequent analyses with data being censored. In reliability research, many articles do simulation, but few explain how they do it. the loss of information resulting from the unavailable exact failure times will impact negatively the efficiency of reliability analysis. This paper presents four different algorithms to generate random data with a different number ...


Comparative transcriptomic response of two Pinus species to infection with the ...

Gaspar, Daniel; Trindade, Cândida; Usié, Ana; Meireles, Brigida; Fortes, Ana Margarida; Guimarães, Joana Bagoin; Simões, Fernanda; Costa, Rita Lourenço

Pine wilt disease (PWD) caused by pine wood nematode (PWN), Bursaphelenchus xylophilus, is a serious threat to global forest populations of conifers, in particular Pinus spp. Recently, the presence of PWN was reported in dead Yunnan pine (Pinus yunnanensis) trees under natural conditions. To further understand the potential impact caused by PWN in Yunnan pine populations, a transcriptional profiling analysis wa...


Genetic diversity and divergence at the Arbutus unedo L. (Ericaceae) westernmos...

Ribeiro, M.M.A.; Piotti, A.; Ricardo, A.; Gaspar, Daniel; Costa, Rita; Parducci, L.; Vendramin, Giovanni Giuseppe

Mediterranean forests are fragile ecosystems vulnerable to recent global warming and reduction of precipitation, and a long-term negative effect is expected on vegetation with increasing drought and in areas burnt by fires. We investigated the spatial distribution of genetic variation of Arbutus unedo in the western Iberia Peninsula, using plastid markers with conservation and provenance regions design purposes...


Application of biophysical factors and molecular markers to explain spatial gen...

Ribeiro, M.M.A.; Quinta-Nova, L.C.; Roque, Natália; Ricardo, Alexandra; Gaspar, Daniel; Costa, Rita

The strawberry tree (Arbutus unedo L.) is a native species, water stress and low fertility soils tolerant, actively resistant to wildfires and widely distributed in Portugal. The fruit is used in the spirit production, the main source of income. Red fruits, with antioxidant potential, represent, also, a new market opportunity. The geographical isolation and extinction-recolonization dynamics are two factors cau...


A política de alarmes na gestão da manutenção de uma indústria farmacêutica

Gaspar, Daniel; Ferreira, Diogo; Coutinho, Joana; Correia, José; Albuquerque, Pedro

Numa organização, é comum a existência de uma estratégia definida para as mais diversas áreas e departamentos. No entanto, é raro encontrar uma política integrada de gestão de alarmes. Os alarmes são vitais para identificação de perigos, riscos, alertas de qualidade e segurança, devendo, por isto mesmo, a sua importância ser valorizada desde o design até à entrada em serviço. Uma política uniformizada de gestão...


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