3 documents found, page 1 of 1
Effects of piperonal nitro derivatives on candida species : antifungal activity...
Andrade Neto, João Batista de; Silva, Cecília Rocha da; Campos, Rosana de Sousa; Nascimento, Francisca Bruna Stefany Aires do; Freitas, Daniel DominguesRecently, there has been a significant increase in invasive fungal infections, the treatment of which is limited to a quite small number of antifungal drugs. Natural products represent an important source of antifungal agents, mainly because of their natural coexistence with fungi present in each biome. Derivatives or semi-synthetic products can be used to optimize the pharmacological profile of natural product...
Evaluation of synergistic effect of kaurenoic acid derivatives with fluconazole...
Andrade Neto, João Batista de; Silva, Cecília Rocha da; Campos, Rosana de Sousa; Nascimento, Francisca Bruna Stefany Aires do; Sampaio, Letícia SerpaCandida species are the fourth most common cause of nosocomial bloodstream infections in the United States and the fifth to tenth most common causative pathogen in European studies Although C. albicans remains the most common fungal isolate recovered from blood, recent reports indicate a trend towards an increasing prevalence of infections caused by species of Candida other than C. albicans which are associated...
Antioxidant properties of antiepileptic drugs levetiracetam and clonazepam in m...
Oliveira, Aline de Albuquerque; Linhares, Maria Isabel; Chaves Filho, Adriano José Maia; Rios, Emiliano Ricardo VasconcelosThis study aimed to investigate the in vitro antioxidant activity of the novel anticonvulsant levetiracetam and benzodiazepine clonazepam. To do this, the mice brain homogenates were incubated with levetiracetam (50, 100 or 200 g/ml) or clonazepam (50, 100 or 200 g/ml), and then, submitted to heating at 37°C for 1 h. Ascorbic acid (vitamin C, 200 g/ml) was used as reference antioxidant drug. The markers of o...