50 documents found, page 1 of 5
Synthesis, Characterization, and Biological Effects of Chloro-Cathinones: Toxic...
Gomes, Ana Patrícia; Ferro, Raquel; Pinto, Daniela; Silva, Joana; Alves, Celso; Pacheco, Rita; Gaspar, HelenaCathinones, a class of synthetic new psychoactive substances (NPSs), continue to emerge and pose public threats. Government control efforts often lead to the emergence of new isomers, which have adverse repercussions on NPSs identification and risk prediction. This work reports on the synthesis and structural characterization of twenty chloro-cathinones, including different isomers, to create analytical data to...
SENTINEL : tackling dangerous nitazene opioids
Maria, Marisa H.; Pereira, Joana R. P.; Ferreira, Daniela R.; Barra, Bárbara F. C.; Antunes, Alexandra M. M.; Família, Carlos; Oliveira-Torres, EditePoster apresentado nas VI Jornadas Científicas Universitárias e Politécnicas Egas Moniz. Monte de Caparica, 24 a 28 de novembro 2025
Comparing Cytotoxic Effects of Synthetic Cathinones and Methamphetamine on Card...
Luís, Cláudia; Vitorino-Oliveira, Cláudia; Gaspar, Helena; Carvalho, Félix; Capela, João Paulo; Costa, Vera MarisaBackground Synthetic cathinones are psychoactive derivatives of the natural drug cathinone. Despite being sold as safer than traditional drugs, over the years there has been a rise in fatalities associated with the cardiotoxic effects of synthetic cathinones [1]. Still, few studies address the mechanisms underlying this toxicity. Objective: This work aimed to study the cardiotoxicity of synthetic cathinones (me...
Sulfated polysaccharides from macroalgae: A simple roadmap for chemical charact...
Martins, Alice; Alves, Celso; Silva, Joana; Pinteus, Susete; Gaspar, Helena; Pedrosa, RuiThe marine environment presents itself as a treasure chest, full of a vast diversity of organisms yet to be explored. Among these organisms, macroalgae stand out as a major source of natural products due to their nature as primary producers and relevance in the sustainability of marine ecosystems. Sulfated polysaccharides (SPs) are a group of polymers biosynthesized by macroalgae, making up part of their cell w...
Synthesis of emerging cathinones and validation of a SPE GC–MS method for their...
Júlio, Sara; Ferro, Raquel A.; Santos, Susana; Alexandre, Andrea; Caldeira, Maria João; Franco, João; Barroso, Mário; Gaspar, HelenaOver the past 15 years, synthetic cathinones have emerged as an important class of new psychoactive substances (NPS) worldwide. The proliferation of these psychostimulants and their sought-after effects among recreational drug users pose a serious threat to public health and enormous challenges to forensic laboratories. For forensic institutions, it is essential to be one step ahead of covert laboratories, fore...
Metabolic stability and metabolite profiling of emerging synthetic cathinones
Lopes, Rita P.; Ferro, Raquel A.; Milhazes, Margarida; Figueira, Margarida; Caldeira, Maria João; Antunes, Alexandra M.M.; Gaspar, HelenaSynthetic cathinones constitute the second largest groups of new psychoactive substances (NPS), which are especially popular among adolescents and young adults. Due to their potential toxicity, the recreational use of these NPS constitute a serious worldwide public health problem. However, their fast appearance in the market renders the continuous updating of NPS information highly challenging for forensic auth...
Disclosing the antitumour potential of the marine bromoditerpene sphaerococceno...
Alves, Celso; Silva, Joana; Afonso, Marta B; Guedes, Romina A.; Guedes, Rita C.; Alvariño, Rebeca; Pinteus, Susete; Gaspar, Helena; Goettert, Márcia I.Nature has revealed to be a key source of innovative anticancer drugs. This study evaluated the antitumour potential of the marine bromoditerpene sphaerococcenol A on different cancer cellular models. Dose-response analyses (0.1-100 µM; 24 h) were accomplished in eight different tumour cell lines (A549, CACO-2, HCT-15, MCF-7, NCI-H226, PC-3, SH-SY5Y, SK-MEL-28). Deeper studies were conducted on MFC-7 cells, nam...
Disclosing the antitumour potential of the marine bromoditerpene sphaerococceno...
Alves, Celso; Silva, Joana; Afonso, Marta B.; Guedes, Romina A.; Guedes, Rita C.; Alvariño, Rebeca; Pinteus, Susete; Gaspar, Helena; Goettert, Marcia I.Nature has revealed to be a key source of innovative anticancer drugs. This study evaluated the antitumour potential of the marine bromoditerpene sphaerococcenol A on different cancer cellular models. Dose-response analyses (0.1–100 μM; 24 h) were accomplished in eight different tumour cell lines (A549, CACO-2, HCT-15, MCF-7, NCI-H226, PC-3, SH-SY5Y, SK-MEL-28). Deeper studies were conducted on MFC-7 cells, nam...
Bromoditerpenes from the red seaweed Sphaerococcus coronopifolius as potential ...
Alves, Celso; Silva, Joana; Pintéus, Susete; Guedes, Romina A.; Guedes, Rita C.; Alvariño, Rebeca; Freitas, Rafaela; Goettert, Márcia I.; Gaspar, HelenaSeaweeds are a great source of compounds with cytotoxic properties with the potential to be used as anticancer agents. This study evaluated the cytotoxic and proteasome inhibitory activities of 12R-hydroxy-bromosphaerol, 12S-hydroxy-bromosphaerol, and bromosphaerol isolated from Sphaerococcus coronopifolius. The cytotoxicity was evaluated on malignant cell lines (A549, CACO-2, HCT-15, MCF-7, NCI-H226, PC-3, SH-...
Exploring marine resources against neurological disorders: the neuroprotective ...
Silva, Joana; Alves, Celso; Susano, Patrícia; Martins, Alice; Pinteus, Susete; Gaspar, Helena; Alfonso, Amparo; Pedrosa, RuiOxidative stress is strongly involved in the pathogenesis of neurodegenerative diseases, like Parkinson´s disease (PD). Particularly, an excess of reactive oxygen species (ROS) released by the cells promotes an oxidative stress condition, which is a main cause of tissue injury leading to nervous system dysfunction. In this work, the antioxidant, neuroprotective and antiinflammatory activities of different fract...