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Immune microenvironment of the omentum in appendicitis: a phenotypic perspectiv...
Marques, Sara; Gaspar, Márcio; Garcez, Fernanda; Batista-Pinto, Carla; Ricardo, Sara; Resende, Albina DoloresBackground: The omentum plays a crucial role in managing inflammation and combating infections, particularly in acute appendicitis [1]. This fat-rich fold of the peritoneum contains lymphoid structures known as “Milky Spots”, which house several types of phenotypically and functionally distinct immune cells, including macrophages and lymphocytes, that contribute to its protective function [1,2]. Among these, T ...
Omentum picture: unraveling the enigma of the immune microenvironment in append...
Gaspar, Márcio; Rodrigues, Tomás; Nunes, Ana Rita; Garcez, Fernanda; Ricardo, Sara; Batista-Pinto, Carla; Resende, Albina DoloresBackground: Appendix obstruction triggers inflammation and exaggerated immune responses, leading the omentum, rich in Milky Spots (MS) housing immune cells, to play a vital role in peritoneal immunity. These MS collect antigens and pathogens, inducing immune responses like inflammation, immune tolerance, or fibrosis [1,2]. Their activities, including angiogenesis, stem cell differentiation, and immune resp...