14 documents found, page 1 of 2
Prevalence of acute and chronic wounds – with emphasis on pressure ulcers – in ...
Furtado, K.; Infante, P.; Sobral, A.; Gaspar, P.; Eliseu, G.; Lopes, M.The aim of the study was to describe the prevalence and general characteristics of acute and chronic wounds in 2018 in Alentejo (Portugal) continuing care units. In order to look at associations, wound characteristics studied were location, type, place of acquisition, number, and duration, and patient characteristics were sex, age, and presence of risk factors. During the first 2 weeks of February 2018, a total...
The disease modelling value of a folklore FAIRYtale: SHEDing light over a speci...
Carvalho, S.; Santos, J.I.; Moreira, L.; Gaspar, P.; Gonçalves, M.; Encarnação, M.; Ribeiro, D.; Duarte, A.; Prata, M.J.; Coutinho, M.F.The problem we are addressing: Despite extensive research, the links between accumulation of glycosaminoglycans (GAGs) and the clinical features seen in patients suffering from various forms of Mucopolysaccharidoses (MPSs) have yet to be further elucidated. These Lysosomal Storage Diseases (LSDs) present symptoms, which may (or may not) include critical musculoskeletal and cardiovascular alterations, respirator...
Study of double parton interactions in diphoton+dijet events in p p collisions ...
Abazov, V. M.; Abbott, B.; Acharya, B. S.; Adams, M.; Adams, T.; Agnew, J. P.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Askew, A.; Atkins, S.Made available in DSpace on 2022-04-28T19:03:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-03-17; Russian Foundation for Basic Research; Ministry of Education and Science of the Russian Federation; We use a sample of diphoton+dijet events to measure the effective cross section of double parton interactions, which characterizes the area containing the interacting partons in proton-antiproton collisio...
Combination of the W boson polarization measurements in top quark decays using ...
Aad, G.; Abbott, B.; Abbott, D. C.; Abud, A. Abed; Abeling, K.; Abhayasinghe, D. K.; Abidi, S. H.; AbouZeid, O. S.; Abraham, N. L.; Abramowicz, H.Made available in DSpace on 2020-12-10T20:14:30Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-08-12; ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW, Austria; FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); NSERC, Canada; CFI, Canada; CONICYT, Chile; NSFC, China;...
Development of RNA based approaches to exploit alternative therapies for Lysoso...
Matos, L.; Santos, J.I.; Rocha, M.; Coutinho, M.F.; Gaspar, P.; Voltolini Velho, R.; Braulke, T.; Prata, M.J.; Alves, S.Treatment strategies such enzyme-replacement therapy and substrate reduction, among others, are available for some Lysosomal Storage Diseases, yet still with some limitations. In recent years, the RNA molecule became one of the most promising targets for therapeutic intervention and currently, a large number of RNA-based therapies are being investigated at the basic research level and in late-stage clinical tri...
Mucopolysaccharidoses type III: toward a siRNA-containing nanoparticle targeted...
Coutinho, M.F.; Santos, J.I.; Gaspar, P.; Alves, S.The classical therapeutic approach for LSD, enzyme replacement therapy, would hardly rise as a potentially successful tool to reduce the disease burden in MPS III patients, as it is long known to have no impact on neuropathology. A tempting alternative, however, would be to block substrate accumulation upstream, by decreasing its synthesis. That concept is known as substrate reduction therapy (SRT). Having this...
Study of double parton interactions in diphoton plus dijet events in p<(p)over ...
Abazov, V. M.; Abbott, B.; Acharya, B. S.; Adams, M.; Adams, T.; Agnew, J. P.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Askew, A.; Atkins, S.Made available in DSpace on 2018-11-26T15:28:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-03-17; Department of Energy and National Science Foundation (USA); Alternative Energies and Atomic Energy Commission (France); National Center for Scientific Research/National Institute of Nuclear and Particle Physics (France); Ministry of Education and Science of the Russian Federation (Russia); National Rese...
Genetically Modulated Substrate Reduction Therapy for Sanfilippo syndrome – pro...
Santos, J.I.; Coutinho, Maria Francisca; Gaspar, P.; Alves, S.Introduction: Mucopolysaccharidosis type III (MPS III) refers to a group of five autosomal recessive neurodegenerative lysosomal storage disorders caused by the incomplete lysosomal degradation of the heparan sulphate (HS) that accumulates in patient cells and triggers disease. The main characteristic of this disease is the degeneration of the central nervous system, resulting in mental retardation and hyperact...
Simultaneous quantitation of sphingoid bases by UPLC-ESI-MS/MS with identical13...
Mirzaian, M.; Wisse, P.; Ferraz, M.J.; Marques, A.R.A.; Gaspar, P.; Oussoren, S.V.; Kytidou, K.; Codée, J.D.C.; van der Marel, G.; Overkleeft, H.S.Free sphingoid bases (lysosphingolipids) of primary storage sphingolipids are increased in tissues and plasma of several sphingolipidoses. As shown earlier by us, sphingoid bases can be accurately quantified using UPLC-ESI-MS/MS, particularly in combination with identical13C-encoded internal standards. The feasibility of simultaneous quantitation of sphingoid bases in plasma specimens spiked with a mixture of s...
A participatory approach to develop new products that promote social valorizati...
Gaspar, P.