Made available in DSpace on 2018-12-11T16:50:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-10-09; Mitogen-activated Protein Kinase Phosphatase 3 (MKP-3) has been involved in the negative regulation of insulin signaling. The absence of MKP-3 is also associated with reduced adiposity, increased energy expenditure and improved insulin sensitivity. The MKP-3 is known as the main Erk1/2 phosphatase and F...