26 documents found, page 1 of 3
Digitalização 3D: expansão da investigação e salvaguarda em museus de arqueologia
Godinho, Ricardo; Lopes, Célia; Curto, Ana; Gaspar, RitaOs museus agregam funções fundamentais na gestão de coleções arqueológicas, incluindo a sua utilização na mediação com o público, o depósito, a conservação e a investigação. São frequentemente procurados por investigadores para estudo de coleções à sua guarda, por vezes com técnicas de análise destrutivas. Embora estes estudos proporcionem dados fundamentais para a compreensão das populações passadas, resultam ...
Lignin extraction from acacia wood: crafting deep eutectic solvents with a syst...
Fernandes, Catarina; Aliaño González, María José; Gomes, Leandro Cid; Bernin, Diana; Gaspar, Rita; Fardim, Pedro; Reis, Marco S.; Alves, LuísLignin is a complex biopolymer whose efficient extraction from biomass is crucial for various applications. Deep eutectic solvents (DES), particularly natural-origin DES (NADES), have emerged as promising systems for lignin fractionation and separation from other biomass components. While ternary DES offer enhanced fractionation performance, the role of each component in these mixtures remains unclear. In this ...
Neonatal testosterone voids sexually differentiated microglia morphology and be...
Simões-Henriques, Carla Filipa; Rodrigues-Neves, A. Catarina; Sousa, Fábio J.; Gaspar, Rita; Almeida, Inês; Baptista, Filipa I.The involvement of immunity in psychiatric disorders, such as anxiety, is typified by the morphologic adaptation of microglia, immune cells of the brain, to anxiogenic stimuli. We previously reported sexually differentiated microglia morphology in adult rodents, in brain locations implicated in anxiety, including the pre-frontal cortex. These physiologic differences likely drive sex-dependent patterns of microg...
The Duration of Stress Determines Sex Specificities in the Vulnerability to Dep...
Gaspar, Rita; Soares-Cunha, Carina; Domingues, Ana Verónica; Coimbra, Bárbara; Baptista, Filipa; Pinto, Luísa; Ambrósio, António; Rodrigues, Ana-JoãoStress exposure has been shown to induce a variety of molecular and functional alterations associated with anxiety and depression. Some studies suggest that microglia, the immune cells of the brain, play a significant role in determining neuronal and behavioral responses to chronic stress and also contribute to the development of stress-related psychopathologies. However, little is known about the impact of the...
Resilience to stress and sex-specific remodeling of microglia and neuronal morp...
Gaspar, Rita; Soares-Cunha, Carina; Domingues, Ana Verónica; Coimbra, Bárbara; Baptista, Filipa I.; Pinto, Luísa; Ambrósio, António; Rodrigues, Ana JoãoPrenatal exposure to stress or glucocorticoids (GC) is associated with the appearance of psychiatric diseases later in life. Microglia, the immune cells of the brain, are altered in stress-related disorders. Synthetic GC such as dexamethasone (DEX) are commonly prescribed in case of preterm risk labour in order to promote fetal lung maturation. Recently, we reported long-lasting differences in microglia morphol...
Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion
Soares-Cunha, Carina; Vasconcelos, Nivaldo António Portela; Coimbra, Bárbara; Domingues, Ana Verónica; Silva, Joana M.; Loureiro-Campos, EduardoDeficits in decoding rewarding (and aversive) signals are present in several neuropsychiatric conditions such as depression and addiction, emphasising the importance of studying the underlying neural circuits in detail. One of the key regions of the reward circuit is the nucleus accumbens (NAc). The classical view on the field postulates that NAc dopamine receptor D1-expressing medium spiny neurons (D1-MSNs) co...
Archaeology of the Pleistocene-Holocene transition in Portugal : Synthesis and ...
Gameiro, Cristina; Aubry, Thierry; Almeida, Francisco; Dimuccio, Luca; Gabriel, Sónia; Gaspar, Rita; Gomes, Sérgio; Valcarce, Ramón FábregasThe Tardiglacial of Portugal has been associated with the Magdalenian culture and lithic industries characterized by tool miniaturization, a diversity of microlith types, and the absence of a intentional blade production. The technological characterization, the chronology and the phasing of the Portuguese Magdalenian have been defined based on data recovered from open-air sites of the Estremadura region (Centra...
Interpretative trajectories towards the understanding of negative features usin...
Jesus, Ana; Tereso, João Pedro; Gaspar, RitaIn prehistoric sites, the most common features identified by archaeologists are negative ones, such as pits, postholes, hearths, sunken hut, and among others. However, interpretations are not easy, and some researchers prefer not to reflect upon them, classifying them as rubbish pits while other researchers argue that these structures have other functions. This paper describes and discusses different types of n...
Archaeology of the Pleistocene-Holocene transition in Portugal: synthesis and p...
Gameiro, Cristina; Aubry, Thierry; Almeida, Francisco; Dimuccio, Luca; Gabriel, Sónia; Gaspar, Rita; Gomes, Sérgio; Valcarce, Ramón FábregasThe Tardiglacial of Portugal has been associated with the Magdalenian culture and lithic industries characterized by tool miniaturization, a diversity of microlith types, and the absence of a intentional blade production. The technological characterization, the chronology and the phasing of the Portuguese Magdalenian have been defined based on data recovered from open-air sites of the Estremadura region (Centra...
Region-specific control of microglia by adenosine A2A receptors: uncoupling anx...
Duarte, Joana Mendes; Gaspar, Rita; Caetano, Liliana; Patrício, Patrícia; Cunha, Carina Isabel Soares; Pinheiro, António Maria Restolho MateusEpidemiologic studies have provided compelling evidence that prenatal stress, through excessive maternal glucocorticoids exposure, is associated with psychiatric disorders later in life. We have recently reported that anxiety associated with prenatal exposure to dexamethasone (DEX, a synthetic glucocorticoid) correlates with a gender-specific remodeling of microglia in the medial prefrontal cortex (mPFC), a cor...