3 documents found, page 1 of 1
Maternal high-fat high-sucrose diet and gestational exercise modulate hepatic f...
Stevanović-Silva, J; Beleza, J; Coxito, P; Pereira, S; Rocha, H; Gaspar, TB; Gärtner, F; Correia, R; Martins, MJ; Guimarães, T; Martins, S; Oliveira, PJBackground Maternal high-caloric nutrition and related gestational diabetes mellitus (GDM) are associated with a high-risk for developing metabolic complications later in life and in their offspring. In contrast, exercise is recognized as a non-pharmacological strategy against metabolic dysfunctions associated to lifestyle disorders. Therefore, we investigated whether gestational exercise delays the development...
Understanding resistance vs. susceptibility in visceral leishmaniasis using mou...
Perez-Cabezas, B; Cecílio, P; Gaspar, TB; Gärtner, F; Vasconcellos, R; Cordeiro-da-Silva, AEvery year, up to 90,000 new cases of Visceral Leishmaniasis and 30,000 resultant deaths are estimated to occur worldwide. Such numbers give relevance to the continuous study of this complex form of the disease: a zoonosis and an anthroponosis; two known etiological agents (Leishmania infantum and L. donovani, respectively); with an estimated average ratio of 1 symptomatic per 10 asymptomatic individuals; and s...
Telomere maintenance mechanisms in cancer
Gaspar, TB; Sá, A; Lopes, JM; Sobrinho-Simões, M; Soares, P; Vinagre, JTumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere shortening, an inevitable process due to successive cell divisions. In most tumour cells, telomere length (TL) is maintained by reactivation of telomerase, while a small part acquires immortality through the telomerase-independent alternative lengthening of telomeres (ALT) mechanism. In the last years, a great amount of data was gen...