48 documents found, page 1 of 5

Editorial

Harvesting the power of green synthesis: gold nanoparticles tailored for prosta...

Biosynthetic gold nanoparticles (bAuNPs) present a promising avenue for enhancing biocompatibility and offering an economically and environmentally responsible alternative to traditional production methods, achieved through a reduction in the use of hazardous chemicals. While the potential of bAuNPs as anticancer agents has been explored, there is a limited body of research focusing on the crucial physicochemic...

Moving towards personalized medicine—The broad use of aptamers for targeted the...

Aptamers are short, single-stranded oligonucleotides synthesized in vitro from a randomized oligonucleotide library against a specific target. These molecules are capable of binding to a wide range of biological targets with high specificity and affinity. They present great advantages over antibodies with potential applications in research, diagnosis, and therapeutics. Specifically for tumors with late-stage id...

Moving towards personalized medicine - the broad use of aptamers for targeted t...

Aptamers are short, single-stranded oligonucleotides synthesized in vitro from a randomized oligonucleotide library against a specific target. These molecules are capable of binding to a wide range of biological targets with high specificity and affinity. They present great advantages over antibodies with potential applications in research, diagnosis, and therapeutics. Specifically for tumors with late-stage id...

A Abordagem Do Delirium Na Doença Oncológica – Uma Revisão

Introdução: O delirium é a complicação neuropsiquiátrica mais comummente identificada na doença oncológica, nomeadamente nos estadios avançados, embora permaneça muitas vezes subdiagnosticada. Objetivos: Os autores pretendem rever a relação entre delirium e doença oncológica, realçando a importância do reconhecimento da comorbilidade e contribuindo para intervenções mais precoces e eficazes. Métodos: Revisão nã...

New CTX‐M group conferring β‐lactam resistance: a compendium of phylogenetic in...

The production of extended‐spectrum β‐lactamases (ESBLs) is the main defense mechanism found in Gram negative bacteria. Among all the ESBLs, the CTX‐M enzymes appear as the most efficient in terms of dissemination in different epidemiological contexts. CTX‐M enzymes exhibit a striking plas-ticity, with a large number of allelic variants distributed in several sublineages, which can be associated with functional...

Cannabidiol and terpene formulation reducing SARS-CoV-2 infectivity tackling a ...

In late 2019, COVID-19 emerged in Wuhan, China. Currently, it is an ongoing global health threat stressing the need for therapeutic compounds. Linking the virus life cycle and its interaction with cell receptors and internal cellular machinery is key to developing therapies based on the control of infectivity and inflammation. In this framework, we evaluate the combination of cannabidiol (CBD), as an anti-infla...

Current trends and challenges of fecal microbiota transplantation—An easy metho...

The gut microbiota refers to bacteria lodges in the gastrointestinal tract (GIT) that interact through various complex mechanisms. The disturbance of this ecosystem has been correlated with several diseases, such as neurologic, respiratory, cardiovascular, and metabolic diseases and cancer. Therefore, the modulation of the gut microbiota has emerged as a potential therapeutic tool; of the various forms of gut m...

New CTX-M group conferring β-Lactam resistance: A compendium of phylogenetic in...

The production of extended-spectrum β-lactamases (ESBLs) is the main defense mechanism found in Gram negative bacteria. Among all the ESBLs, the CTX-M enzymes appear as the most efficient in terms of dissemination in different epidemiological contexts. CTX-M enzymes exhibit a striking plasticity, with a large number of allelic variants distributed in several sublineages, which can be associated with functional ...

Enhanced 3T3-L1 differentiation into adipocytes by pioglitazone pharmacological...

Despite the primary function of pioglitazone in antidiabetic treatment, this drug is a potent inducer of PPAR-γ, a crucial receptor that is involved in adipocyte differentiation. In this work, we propose an optimized methodology to enhance the differentiation of 3T3-L1 fibroblasts into adipocytes. This process is crucial for adipocyte secretome release, which is fundamental for understanding the molecular mecha...