2 documents found, page 1 of 1
Association Study of 83 Candidate Genes for Bipolar Disorder in Chromosome 6q S...
Bigdeli, Bernard; Maher, Brion S.; Zhao, Zhongming; Sun, Jingchun; Medeiros, Helena; Akula, Nirmala; McMahon, Francis J.; Carvalho, CéliaBackground: Prior genome-scans of bipolar disorder have revealed chromosome 6q22 as a promising candidate region. However, linkage disequilibrium (LD) mapping studies have yet to identify replicated susceptibility loci. Methods: We analyzed 1,422 LD-tagging single nucleotide polymorphisms (SNPs) in 83 genes to test single-marker and locus-wide evidence of association with bipolar disorder in the NIMH Genetics I...
Genetic Overlap of Schizophrenia and Bipolar Disorder in a High-Density Linkage...
Fanous, Ayman H.; Middleton, Frank A.; Gentile, Karen; Amdur, Richard L.; Maher, Brion S.; Zhao, Zhongming; Sun, Jingchun; Medeiros, HelenaRecent family and genome-wide association studies strongly suggest shared genetic risk factors for schizophrenia (SZ) and bipolar disorder (BP). However, linkage studies have not been used to test for statistically significant genome-wide overlap between them. Forty-seven Portuguese families with sibpairs concordant for SZ, BP, or psychosis (PSY, which includes either SZ or psychotic BP) were genotyped for over...