9 documents found, page 1 of 1
Recent advances and perspectives of MicroNeedles for biomedical applications
Maia, Renata Faria; Machado, Pedro; Rodrigues, Raquel Oliveira; Faustino, Vera Luísa Carreira; Schütte, Helmut; Gassmann, Stefan; Lima, Rui A.Microneedles (MN) technology has emerged as a transformative tool within the biomedical field, offering innovative solutions to challenges in drug delivery, diagnostics, and therapeutic applications. This review article provides an in-depth exploration of the diverse perspectives and applications of MNs, shedding light on their pivotal role in shaping the future of biomedical research and clinical practice. It ...
Optical sensor system to monitor the pH of circulating media on biomimetic micr...
Mendes, Fernando; Miranda, Inês Sofia Ferreira; Rodrigues, Raquel Oliveira; Ferreira, Gabriel Malheiro; Schütte, Helmut; Gassmann, StefanpH is a physiological parameter of great importance in biomedical research. For example, during cell growth process, pH is usually lowered due to the acidic metabolites released by the cells. This decrease on the pH value can affect biological processes and, consequently, affect the accuracy of the research. To monitor the pH changes along cell engineering experiments, cell culture media is usually complemented...
Separation microfluidic device fabricated by micromilling techniques
Gonçalves, Inês Maia; Madureira, Miguel; Miranda, Inês; Schütte, Helmut; Moita, Ana; Minas, Graça; Gassmann, Stefan; Lima, Rui Alberto Madeira MacedoThe diagnosis of several diseases can be performed by analyzing the blood plasma of a patient. Despite extensive research work, there is still a need to improve current low-cost fabrication techniques and devices for the separation of plasma from blood cells. Microfluidic biomedical devices have great potential for that process. Hence, a microfluidic device made by micromilling and sealed with an oxygen plasma ...
Red blood cells separation in a curved T-shaped microchannel fabricated by a mi...
Madureira, Miguel; Faustino, Vera; Schütte, Helmut; Pinho, Diana; Minas, Graça; Gassmann, Stefan; Lima, Rui Alberto Madeira MacedoBiomedical microfluidic devices are fabricated using different fabrication technologies. The most popular method is the soft-lithography manly due their main attraction, its high resolution capabilities and low material cost. However, usually, the fabrication of the moulds to produce microfluidic devices, is performed in a cleanroom environment and with specialized equipment that can be quite time consuming and...
In vitro blood flow and cell-free layer in hyperbolic microchannels: visualizat...
Rodrigues, Raquel Oliveira; Lopes, Raquel; Pinho, Diana; Pereira, Ana I.; Garcia, Valdemar; Gassmann, Stefan; Sousa, Patrícia C.; Lima, Rui A.Red blood cells (RBCs) in microchannels has tendency to undergo axial migration due to the parabolic velocity profile, which results in a high shear stress around wall that forces the RBC to move towards the centre induced by the tank treading motion of the RBC membrane. As a result there is a formation of a cell free layer (CFL) with extremely low concentration of cells. Based on this phenomenon, several works...
Blood flow visualization and measurements in microfluidic devices fabricated by...
Singhal, Jaron; Pinho, Diana; Lopes, Raquel; Sousa, Patrícia C.; Garcia, Valdemar; Schütte, Helmut; Lima, Rui A.; Gassmann, StefanThe most common and used technique to produce microfluidic devices for biomedical applications is the soft-lithography. However, this is a high cost and time-consuming technique. Recently, manufacturers were able to produce milling tools smaller than 100 μm and consequently have promoted the ability of the micromilling machines to fabricate microfluidic devices capable of performing cell separation. In this wor...
Low cost microfluidic device for partial cell separation: micromilling approach
Lopes, Raquel; Rodrigues, Raquel Oliveira; Pinho, Diana; Valdemar, Garcia; Schütte, Helmut; Lima, Rui A.; Gassmann, StefanSeveral studies have already demonstrated that it is possible to perform blood flow studies in microfluidic systems fabricated by using low-cost techniques. However, most of these techniques do not produce microchannels smaller than 100 microns and as a result they have several limitations related to blood cell separation. Recently, manufacturers have been able to produce milling tools smaller than 100 microns,...
Low cost microfluidic device for partial cell separation: micromilling approach
Lopes, Raquel; Rodrigues, Raquel O.; Pinho, Diana; Garcia, Valdemar; Schütte, Helmut; Lima, Rui Alberto Madeira Macedo; Gassmann, StefanSeveral studies have already demonstrated that it is possible to perform blood flow studies in microfluidic systems fabricated by using low-cost techniques. However, most of these techniques do not produce microchannels smaller than 100 microns and as a result they have several limitations related to blood cell separation. Recently, manufacturers have been able to produce milling tools smaller than 100 microns,...
Blood flow visualization and measurements in microfluidic devices fabricated by...
Singhal, Jaron; Pinho, Diana; Lopes, Raquel; Sousa, Patricia C.; Garcia, Valdemar; Schütte, Helmut; Lima, Rui Alberto Madeira Macedo; Gassmann, StefanThe most common and used technique to produce microfluidic devices for biomedical applications is the soft-lithography. However, this is a high cost and time-consuming technique. Recently, manufacturers were able to produce milling tools smaller than 100 m and consequently have promoted the ability of the micromilling machines to fabricate microfluidic devices capable of performing cell separation. In this work...