8 documents found, page 1 of 1
Caryocar brasiliense camb protects against genomic and oxidative damage in uret...
Colombo, N. B. R.; Rangel, M. P.; Silva, Vanessa Martins da; Hage, Marcia; Gelain, Daniel Pens; Barbeiro, Denise Frediani; Grisolia, Cesar KoppeThe antioxidant effects of Caryocar brasiliense Camb, commonly known as the pequi fruit, have not been evaluated to determine their protective effects against oxidative damage in lung carcinogenesis. In the present study, we evaluated the role of pequi fruit against urethane-induced DNA damage and oxidative stress in forty 8-12 week old male BALB/C mice. An in vivo comet assay was performed to assess DNA damage...
Chemical composition, antinociceptive, anti-inflammatory and redox properties i...
Rabelo, Alessandra Silva; Serafini, Mairim Russo; Rabelo, Thallita Kelly; Melo, Marcelia Garcez Dória de; Prado, Douglas da Silva; Gelain, Daniel PensMethods: The essential oil from the roots and rhizomes of RMO were obtained by hydrodistillation using a Clevenger apparatus, and analyzed by gas chromatography/mass spectrometry (GC/MS). Here, we evaluated free radical scavenging activities and antioxidant potential of RMO using in vitro assays for scavenging activity against hydroxyl radicals, hydrogen peroxide, superoxide radicals, and nitric oxide. The tota...
Major components of energy drinks (caffeine, taurine, and guarana) exert cytoto...
Zeidán-Chuliá, Fares; Gelain, Daniel Pens; Kolling, Eduardo Antônio; Rybarczyk-Filho, José Luiz [UNESP]; Ambrosi, Priscilla; Resende Terra, SilviaSubmitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:29:40Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:32:38Z : No. of bitstreams: 1 2-s2.0-84878680462.pdf: 16796911 bytes, checksum: da5683aaa10a345e105b8e5b6372639e (MD5); Made available in DSpace on 2014-05-27T11:29:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-06-12; Scope. To elucidate the morpholog...
Morinda citrifolia linn leaf extract possesses antioxidant activities and reduc...
Serafini, Mairim Russo; Santos, Rodrigo Correia; Guimarães, Adriana Gibara; Santos, João Paulo Almeida dos; Santos, Alan Diego da ConceiçãoThis is a copy of an article published in the Journal of Medicinal Food© 2011 - copyright Mary Ann Liebert, Inc.; Journal of Medicinal Food is available online at: http://online.liebertpub.com; Herbal drugs have been used since ancient times to treat a wide range of diseases. Morinda citrifolia Linn (popularly known as ‘‘Noni’’) has been used in folk medicine by Polynesians for over 2,000 years. It is reported ...
Phytochemical screening, antinociceptive and anti-inflammatory activities of Ch...
Lima, Gabrielle Mendes; Quintans-Júnior, Lucindo José; Thomazzi, Sara Maria; Almeida, Emyle Mayra Santana Alves; Melo, Mônica Santos deChrysopogon zizanioides (L.) Roberty, Poaceae, is a plant widely used in northeast Brazil in folk medicine for the treatment of various pathological conditions, including inflammatory pain. The present study evaluated the antinociceptive and anti-inflammatory effects of C. zizanioides essential oil (EO) in rodents. EO was further characterized by GC/MS. The major components of EO were identified as khusimol (19...
Antioxidant, Antinociceptive, and Anti-inflammatory Properties of the Ethanolic...
Gouveia, Marcos Guilherme de Souza; Xavier, Maria Aldenise; Barreto, André Sales; Gelain, Daniel Pens; Santos, João Paulo Almeida dosThis is a copy of an article published in the Journal of Medicinal Food© 2011 - copyright Mary Ann Liebert, Inc.; Journal of Medicinal Food is available online at: http://online.liebertpub.com; The antioxidant, antinociceptive, and anti-inflammatory activities of the ethanolic extract from leaves of Combretum duarteanum (EEC) were assessed in rodents through in vitro tests. The antioxidant activity was investig...
Sinalização não-genômica do retinol mediada por espécies reativas
Gelain, Daniel PensO retinol (vitamina A) exerce papéis fundamentais na regulação de processos celulares, tais como crescimento, divisão e apoptose. Os efeitos do retinol em nível celular são classicamente atribuídos à ativação de receptores nucleares da família dos receptores esteróides, conhecidos como RAR e RXR. Esses receptores são ativados por diferentes isômeros do ácido retinóico, que é considerado o produto mais biologica...
Purinas extracelulares em células isoladas de túbulos seminíferos
Gelain, Daniel PensAs purinas extracelulares, principalmente ATP e adenosina, exercem diversos efeitos sinalizadores através da sua interação com receptores de membrana específicos, denominados receptores purinérgicos. Desde o início da década de 1980, tem sido observada a presença de receptores purinérgicos em células do sistema reprodutor masculino, em especial células de Sertoli e células germinativas. Foi descrito que as célu...