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Distinctive clinical phenotype of anti-centromere antibody-positive diffuse sys...

Caetano, J; Nihtyanova, S; Harvey, J; Denton, C; Ong, V

OBJECTIVES: The aim was to define clinical characteristics and long-term survival of patients with dcSSc and positive ACA. METHODS: We identified all cases of ACA+ SSc in our cohort (n = 1313). Those with dcSSc (ACA+ diffuse) were compared with representative groups of consecutive ACA+ patients with limited subset (ACA+ limited) and ACA- dcSSc (non-ACA diffuse). RESULTS: Thirty-five patients (2.7%) were ACA+ di...


Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost,...

Fitzmaurice, C; Akinyemiju, T; Al Lami, F; Alam, T; Alizadeh-Navaei, R; Allen, C; Alsharif, U; Alvis-Guzman, N; Amini, E; Anderson, B; Aremu, O

Importance: The increasing burden due to cancer and other noncommunicable diseases poses a threat to human development, which has resulted in global political commitments reflected in the Sustainable Development Goals as well as the World Health Organization (WHO) Global Action Plan on Non-Communicable Diseases. To determine if these commitments have resulted in improved cancer control, quantitative assessments...


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