2 documents found, page 1 of 1
Clinical, histological and molecular profiling of different stages of alcohol-r...
Ventura-Cots, Meritxell; Argemi, Josepmaria; Jones, Patricia D; Lackner, Carolin; El Hag, Mohamed; Abraldes, Juan G; Alvarado, Edilmar; Clemente, AnaObjective: Alcohol-related liver disease (ALD) ranges from never-decompensated ALD (ndALD) to the life-threatening decompensated phenotype, known as alcohol-related hepatitis (AH). A multidimensional study of the clinical, histological and molecular features of these subtypes is lacking. Design: Two large cohorts of patients were recruited in an international, observational multicentre study: a retrospective co...
Liver Phenotypes of European Adults Heterozygous or Homozygous for Pi∗Z Variant...
Schneider, Carolin V.; Hamesch, Karim; Gross, Annika; Mandorfer, Mattias; Moeller, Linda S.; Pereira, Vitor; Pons, Monica; Kuca, PawelHomozygosity for the Pi∗Z variant of the gene that encodes the alpha-1 antitrypsin peptide (AAT), called the Pi∗ZZ genotype, causes a liver and lung disease called alpha-1 antitrypsin deficiency. Heterozygosity (the Pi∗MZ genotype) is a risk factor for cirrhosis in individuals with liver disease. Up to 4% of Europeans have the Pi∗MZ genotype; we compared features of adults with and without Pi∗MZ genotype among ...