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Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Me...
Comandolli-Wyrepkowski, Claudia Dantas; Grafova, Iryna; Naiff, Maricleide de Farias; Avella, Maurizio; Gentile, Gennaro; Grafov, Andrèi AndriyCurrent treatment of cutaneous leishmaniasis (CL) relies mainly on pentavalent antimonials salts and second-line drugs include pentamidine and amphotericin B, but these therapies have side effects and require parenteral administration. The aim of this work was to evaluate the topical formulations containing pentamidine isethionate (PI) in the experimental treatment of cutaneous leishmaniasis (CL). Golden hamste...
Nanoscaled hydrated antimony (V) oxide as a new approach to first-line antileis...
Franco, A. M.; Grafova, Iryna A.; Soares, Fabiane Veloso; Gentile, Gennaro; Wyrepkowski, Claudia D C; Bolson, Marcos A.; Sargentini, ÉzioBackground: Coordination compounds of pentavalent antimony have been, and remain, the first-line drugs in leishmaniasis treatment for >70 years. Molecular forms of Sb (V) complexes are commercialized as sodium stibogluconate (Pentostam®) and meglumine antimoniate (MA) (Glucantime®). Ever-increasing drug resistance in the parasites limits the use of antimonials, due to the low drug concentrations being administe...