2 documents found, page 1 of 1
Genetic linkage of bipolar disorder to chromosome 6q22 is a consistent finding ...
Pato, Carlos N.; Middleton, Frank A.; Gentile, Karen L.; Morley, Christopher P.; Medeiros, Helena; Macedo, António; Azevedo, M. Helena; Pato, Michele T.We recently reported genome-wide significant linkage to chromosome 6q for bipolar disorder, in a study of 25 Portuguese families, using the Human Mapping Assay Xba 131 (HMA10K). To explore the generalizability of this finding, we reanalyzed our SNP linkage data according to the families' geographic origin. Specifically, the 25 families included 20 families from the Portuguese island collection (PIC; 15 families...
Gene expression analysis of peripheral blood leukocytes from discordant sib-pai...
Middleton, Frank A.; Pato, Carlos N.; Gentile, Karen L.; McGann, Lindsay; Brown, Andrea M.; Trauzzi, Marco; Diab, Heba; Morley, Christopher P.We performed global RNA transcript analysis and comprehensive gene group analysis of peripheral blood leukocyte (PBL) RNA from two groups of matched sib-pairs that were discordant for either schizophrenia (n = 33 sib-pairs) or bipolar disorder (n = 5 sib-pairs). The pairs chosen for these analyses were selected from families with known patterns of genetic linkage (5q for schizophrenia and 6q for bipolar disorde...