15 documents found, page 1 of 2
Diagnosis and Laboratory Follow-Up of Patients with Multiple Myeloma: Guideline...
Pires, Ana Marta; Barreto, João Pedro; Caetano, Joana; Soares, Maria José; Geraldes, Catarina; Fernandes, Bruno; Coucelo, Margarida; Chacim, SérgioMultiple myeloma is a neoplasm of plasma cells that in most cases is associated with the secretion of monoclonal immunoglobulins and can involve multiple organs. Its timely diagnosis is essential to limit or avoid irreversible damage and dysfunction of target organs. Appropriate initial stratification of patients allows for optimization in the selection and sequence of therapy, as well as proper follow-up durin...
Colours of the Tijomel ceramic manufacture (1941-1992): characterisation of a s...
Coutinho, Mathilda; Pereira, Silvia; Ruivo, Andreia; Bottura-Scardina, Silvia; Veiga, João Pedro; Geraldes, Catarina; Gil, Milene; Shearman, JoanaColours of the Tijomel ceramic manufacture (1941-1992): characterisation of a set of ceramic colourants and glazed tiles from Decormel Materials Catalogue
Diagnosis and laboratory follow-up of patients with multiple myeloma: guideline...
Pires, Ana Marta; Barreto, João Pedro; Caetano, Joana; Soares, Maria José; Geraldes, Catarina; Fernandes, Bruno; Coucelo, Margarida; Chacim, SérgioMultiple myeloma is a neoplasm of plasma cells that in most cases is associated with the secretion of monoclonal immunoglobulins and can involve multiple organs. Its timely diagnosis is essential to limit or avoid irreversible damage and dysfunction of target organs. Appropriate initial stratification of patients allows for optimization in the selection and sequence of therapy, as well as proper follow-up durin...
Colours of the Tijomel ceramic manufacture (1941-1992): characterisation of a s...
Coutinho, Mathilda; Pereira, Silvia; Ruivo, Andreia; Bottura-Scardina, Silvia; Veiga, João Pedro; Geraldes, Catarina; Gil, Milene; Shearman, JoanaTijomel was considered one of the most modern ceramic manufacturers in the Iberian Peninsula in the mid-20th century. Located at Caxarias (Ourém, Portugal), this manufacturer produced diverse ceramic-based architectural materials, from common clay bricks to sophisticated modernist azulejos. Recently members of the family of the former Tijomel Manufacture owners retrieved a collection of 33 raw materials, mostly...
CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukem...
Rodrigues, Cristiana; Laranjeira, Paula; Pinho, A. C. O.; Silva, Isabel; Silva, Sandra; Coucelo, Margarida; Oliveira, Ana Catarina; Simões, Ana TeresaIntroduction: In monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions between B cells and T cells, leading to immune dysregulation. CD20+ T cells are a subpopulation of T cells that appear to be involved in autoimmune diseases and cancer. Methods: Here, we quantified and phenotypically characterized CD20...
Largo das Belas-Artes, v. 03, n.º 03 - Arquiteturas Brilhantes (dez. 2024)
Gonçalves, Luís Jorge Rodrigues; Silva, Álvaro Fernando Duarte de Sousa; Sousa, Ana Cláudia Encarnação de; Bento, Carina; Geraldes, CatarinaA Revista Largo das Belas-Artes, Volume 03, número 03 – Arquiteturas Brilhantes, reúne um conjunto de textos que abordam diferentes perspetivas sobre o azulejo, em Portugal. A obra surgiu da iniciativa de um conjunto de alunos de doutoramento em Belas-Artes, na especialidade de Ciências da Arte e do Património, da Faculdade de Belas-Artes da Universidade de Lisboa, que organizaram um encontro com o título referido
Antibiotic heteroresistance and persistence: an additional aid in hospital acqu...
Geraldes, Catarina; Tavares, Luís; Gil, Solange; Oliveira, ManuelaEnterococcus, particularly E. faecium and E. faecalis, are responsible for many hospital-acquired infections. With their intrinsic antibiotic resistance and ability to form biofilms, enterococcal infections are already challenging to manage. However, when heterogenous populations are present, such as those exhibiting heteroresistance and persistence, the complexity of these infections increases exponentially no...
Parthenolide Induces ROS-Mediated Apoptosis in Lymphoid Malignancies
Jorge, Joana; Neves, Joana; Alves, Raquel; Geraldes, Catarina; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana BelaLymphoid malignancies are a group of highly heterogeneous diseases frequently associated with constitutive activation of the nuclear factor kappa B (NF-κB) signaling pathway. Parthenolide is a natural compound used to treat migraines and arthritis and found to act as a potent NF-κB signaling inhibitor. This study evaluated in vitro parthenolide efficacy in lymphoid neoplasms. We assessed parthenolide metabolic ...
Multiple Myeloma Treatment Guidelines by the Portuguese Group of Multiple Myeloma
João, Cristina; Bergantim, Rui; Santos, Joana; Afonso, Celina; Bernardo, Paulo; Coelho, Henrique; Costa, Carlos; Esteves, Graça; Freitas, José GuilhermeThe treatment of multiple myeloma has profoundly changed with the introduction of several innovative therapies. The optimization of therapeutic sequencing through the combined use of the various drugs developed in recent years and the attention given to the characteristics of patients have allowed the reduction of toxicities and increased survival and quality of life of patients with multiple myeloma. These tre...
Practical Considerations for the Daratumumab Management in Portuguese Routine C...
Geraldes, Catarina; Neves, Manuel; Chacim, Sérgio; da Costa, Fernando LealThe recent therapeutic progress in multiple myeloma (MM) has led to the introduction of novel and highly potent drug classes. Daratumumab was the first CD38-targeting antibody showing to be effective and safe in MM patients as monotherapy and in combination regimens, which led to its rapid implementation in clinical practice. Considering that treatment discontinuation for drug-related adverse events can impact ...