10 documents found, page 1 of 1
Isolation, structural identification and cytotoxic activity of hexanic extract,...
Fernandes,Elaine de S.; Rodrigues,Fátima A.; Tófoli,Danilo; Imamura,Paulo M.; Carvalho,João E. de; Ruiz,Ana L. T. G.; Foglio,Mary A.; Minguzzi,SandroThe cytotoxicity of a hexanic fraction produced from the ethanolic crude extract, obtained from Jatropha ribifolia (Pohl) Baill, Euphorbiaceae, roots was evaluated against ten human cancer cell lines (MCF-7, NCI-ADR/RES, OVCAR-3, PC-3, HT-29, NCI-H460,786-O, UACC-62, K-562, U251) compared with doxorrubicine as positive control. Compounds jatrophone and cyperenoic acid were isolated from the hexanic extract and ...
Resolução do ibuprofeno: um projeto para disciplina de química orgânica experim...
Romero,Adriano L.; Baptistella,Lúcia H. B.; Coelho,Fernando; Imamura,Paulo M.A practical and didactic sequence of experiments was proposed to illustrate the stereochemistry concept, optically active compounds, resolution of racemates, and use of the NMR technique, including 2D-COSY for identification of organic compounds, on a laboratory course for undergraduate students. The sequence was: extractions of racemic ibuprofen and chiral naproxen from commercial tablets; syntheses of diaster...
Anti-oxidative and anti-ulcerogenic activity of Ipomoea imperati
Miyahara,Maria Regina M.; Imamura,Paulo M.; Freitas,José C. De; Leonor,Sérgio J.; Baffa,Oswaldo; Kinoshita,Angela; Paula-Zurron,Ana Claudia B. DeIpomoea imperati (Vahl) Griseb., Convolvulaceae, is used in traditional medicine for the treatment of inflammation, swelling and wounds, as well as to treat pains and stomach problems. This work evaluates the anti-oxidative activity by ESR (Electron Spin Resonance spectroscopy) and the preventive and curative actions of I. imperati in gastric ulcer animal model. Ipomoea imperati (200 mg/kg, p.o.) prevented the ...
Antinociceptive activity of Ipomoea imperati (Vahl) Griseb., Convolvulaceae
Paula-Zurron,Ana Claudia B. De; Petraglia,Nilva M. M. A.; Aur,Carlos R.; Moura,Sérgio H. P.; Imamura,Paulo M.; Freitas,José C. DeIpomoea imperati (Vahl) Griseb., Convolvulaceae, is used in folk medicine for the treatment of inflammation, swelling and wounds, as well as to treat pains after childbirth and for stomach problems. Administration of ethanol extract, lipid and aqueous fraction of I. imperati(300, 100 and 200 mg/kg) significantly inhibited the abdominal constriction in mice induced by acetic acid; increased the sleeping time evo...
Absolute configuration of some dinorlabdanes from the copaiba oil
Romero,Adriano L.; Baptistella,Lúcia H. B.; Imamura,Paulo M.A novel ent-dinorlabdane (-)-13(R)-14,15-dinorlabd-8(17)-ene-3,13-diol was isolated from commercial copaiba oil along with two known dinorlabdanes. The absolute configuration of these dinorditerpenes was established for the first time through synthesis starting from known (-)-3-hydroxycopalic acid, which was also isolated from the same oleoresin.
Synthesis of Ent-16-hydroxycleroda-4(18),13-dien-15,16-olide and Ent-cleroda-4(...
Ide,Regina M.; Costa,Marta; Imamura,Paulo M.The absolute configurations of two natural diterpene butenolides were confirmed through the synthesis of ent-16-hydroxycleroda-4(18),13-dien-15,16-olide (2) and ent-cleroda-4(18),13-dien-15,16-olide (3), enantiomers of the natural products, starting from (+)-hardwickiic acid (1).
Síntese dos analgésicos paracetamol e fenacetina e do adoçante dulcina: um proj...
Baptistella,Lúcia H. B.; Giacomini,Rosana A.; Imamura,Paulo M.A synthesis of artificial sweetener dulcin starting from nitrobenzene was elaborated for undergraduate organic laboratory course. Paracetamol and phenacetin, both physiologically active analgesic compounds, were also prepared as intermediates. Besides a large scope of discussion subjects related with organic synthesis, interesting lectures about analgesics and sweeteners may also be performed in this project. T...
Chemical transformation of abietic acid to new chiral derivatives
Santos,Catarina dos; Zukerman-Schpector,Julio; Imamura,Paulo M.Chemical transformations of the C-ring abietic acid (1a) for the preparation of some new chiral synthons are described. From the intermediate keto-aldehyde 9, readily available from 1b through the ozonide 2, the new tetracyclic diterpene 4 was synthesized. Additionally, from 13 and 17, previously prepared from 2, the bicyclic compounds 14, 15 and 16 and the derivatives containing the abeo-abietane[6,6,5] framew...
A New ent-Clerodane Diterpene from Hymenaea courbaril var. altissima
Nogueira,Raquel T.; Giacomini,Rosana A.; Shepherd,George J.; Imamura,Paulo M.A new ent-clerodane and two known ent-labdanes were isolated from the barks of Hymenaea courbaril var. altissima (Ducke). The new diterpene was identified, after esterification with diazomethane, as methyl (-)-(5R,8S,9S,10R)-clerod-3-en-15-oate and known diterpenes were identified as methyl (-)-copalate and methyl (-)-eperuate. From the EtOAc extract of seed pods a known methyl (-)-zanzibarate was isolated. The...
Synthetic studies with Pinus elliottiis rosin derivatives. Oxidation of maleopi...
Hess,Sonia C.; Farah,Maria I. S.; Eguchib,Silvia Y.; Imamura,Paulo M.Ozonolysis of maleopimaric anhydride methyl ester in the presence of tetracyanoethylene led to an epoxide and an ozonide. Ozonolysis of the trimethyl fumaropimarate, followed by treatment with Me2S, led to an epoxide, a diene, a keto-acid and an allylic oxidation product. Some of the compounds obtained were active against Staphylococcus aureus, Bacillus subtilis and Micrococcus luteus.