11 documents found, page 1 of 2
Harvesting the power of green synthesis: gold nanoparticles tailored for prosta...
Oliveira, Marco; Sousa, André; Sá, Sara; Soares, Sílvia; Pereira, Ana Cláudia; Rocha, Ana Catarina; Pais, Patrick; Ferreira, Diogo; Almeida, CátiaBiosynthetic gold nanoparticles (bAuNPs) present a promising avenue for enhancing biocompatibility and offering an economically and environmentally responsible alternative to traditional production methods, achieved through a reduction in the use of hazardous chemicals. While the potential of bAuNPs as anticancer agents has been explored, there is a limited body of research focusing on the crucial physicochemic...
The magic cocktail: ampicillin and biosynthesized gold nanoparticles synergism ...
Oliveira, Marco; Soares, Silvia; Sá, Sara; Gestoso, Álvaro; Correa-Duarte, Miguel; Baylina, Pilar; Fernandes, Rúben; Pereira, Carla F.Gold nanoparticles (AuNPs) have garnered attention as a potential alternative to conventional antibiotics due to their innovative antibacterial properties. This study demonstrates the successful production of biosynthetic gold nanoparticles (bAuNPs) using Pseudomonas aeruginosa (P. aeruginosa) as spherical nanostructures at 58 °C for 24 h, under alkaline pH (9.0). The successful synthesis of bAuNPs was confirme...
Cutibacterium acnes dysbiosis: Alternative therapeutics for clinical application
Sá, Sara; Fernandes, Ruben; Gestoso, Álvaro; Macedo, José Mário; Martins-Mendes, Daniela; Pereira, Ana Cláudia; Baylina, PilarCutibacterium acnes (C. acnes) is a Gram-positive anaerobic facultative bacterium that is part of the human skin commensal microbiome. It colonizes various regions of the body, including the face, back, and chest. While typically a harmless commensal, under certain conditions, C. acnes can become pathogenic, leading to or promoting conditions such as acne vulgaris (AV), post-surgical infections, prostate cancer...
Unveiling the path to resilience: prioritizing mental health, sleep, and nutrit...
Ramalho, Susana; Martins-Mendes, Daniela; Macedo, José Mário; Barros, Carla; Luís, Carla; Sá, Sara; Gestoso, Álvaro; Pereira, Ana CláudiaThe COVID-19 pandemic has disrupted daily life, impacting relationships, work, and education. This has led to increased stress, anxiety, and depression, along with altered sleep patterns and eating behaviors. Quarantine and isolation have worsened mental health, especially in children and the elderly, due to the loss of activities and physical contact. Sleep disorders and negative dreams perpetuate poor sleep q...
The magic cocktail: Ampicillin and Biosynthesized gold nanoparticles synergism ...
Oliveira, Marco; Soares, Sílvia; Sá, Sara; Gestoso, Álvaro; Correa-Duarte, Miguel; Baylina, Pilar; Fernandes, Rúben; Pereira, Carla F.Gold nanoparticles (AuNPs) have garnered attention as a potential alternative to conventional antibiotics due to their innovative antibacterial properties. This study demonstrates the successful production of biosynthetic gold nanoparticles (bAuNPs) using Pseudomonas aeruginosa (P. aeruginosa) as spherical nanostructures at 58 ◦C for 24 h, under alkaline pH (9.0). The successful synthesis of bAuNPs was confirme...
Exploring the anti-cancer properties of pomegranate peel aqueous extract
Luís, Carla; Sousa, André P.; Costa, Raquel; Maduro, Ana T.; Pais, Patrick J.; Sá, Sara; Gestoso, Álvaro; Fernandes, Flávia; Jerónimo, ElianaThe objective of this work is to evaluate the influence of pomegranate peel extract (PPE) in the behavior of breast cell lines (epithelial and tumor type) and related oxidative metabolism. Fruitbased functional foods have been the target of increasing scientific research for their physiological and pathophysiological properties. Pomegranate (Punica granatum) is a suitable example with both prophylactic and medi...
Moving towards personalized medicine—The broad use of aptamers for targeted the...
Sousa, André P.; Rocha, Ana C.; Almeida, Cátia; Carneiro, Mariana C. C. G.; Pais, Patrick P.; Viana, Rejane; Fernandes, Rúben; Barata, PedroAptamers are short, single-stranded oligonucleotides synthesized in vitro from a randomized oligonucleotide library against a specific target. These molecules are capable of binding to a wide range of biological targets with high specificity and affinity. They present great advantages over antibodies with potential applications in research, diagnosis, and therapeutics. Specifically for tumors with late-stage id...
Virulence-linked mutations in rubredoxin reductase and glutaredoxin: impact on ...
Sá, Sara; Silva, Carina; Dias, Maria Clara; Veiga, Marlene; Lopes, Sofia; Fernandes, Ruben; Rocha, Ana Catarina; Pais, Patrick J.; Oliveira, MarcoPseudomonas aeruginosa (PAO1) is an opportunistic pathogen, lethal in immunocompromised individuals. The clinical management of PAO1 infections still depends deeply on antibiotic therapy. However, this therapy has been alarmingly overpowered by growing bacterial resistance mechanisms over the years. One of these bacterial mechanisms is quorum sensing (QS). QS is involved in the production of biofilm, rhamnolipi...
Moving towards personalized medicine - the broad use of aptamers for targeted t...
Sousa, André P.; Rocha, Ana C.; Almeida, Cátia; Carneiro, Mariana C. C. G.; Pais, Patrick P.; Viana, Rejane; Fernandes, Rúben Rodrigues; Barata, PedroAptamers are short, single-stranded oligonucleotides synthesized in vitro from a randomized oligonucleotide library against a specific target. These molecules are capable of binding to a wide range of biological targets with high specificity and affinity. They present great advantages over antibodies with potential applications in research, diagnosis, and therapeutics. Specifically for tumors with late-stage id...
High resistance to fourth-generation cephalosporins among clinical isolates of ...
Prudêncio, Cristina; Gestoso, Álvaro; Freitas, José Mota; Santos, Perpétua; Prudêncio, Cristina; Fernandes, Ruben; Fernandes, RúbenHere we report the molecular and antimicrobial susceptibility profile of extended-spectrum β-lactamase (ESBL)-producing strains found in the Portuguese northern occidental coast region (Minho). For this purpose, bacteria isolated from clinical hospitalised and non-hospitalised patients over a period of 2 years were identified and minimal inhibitory concentrations (MICs) were determined by microdilution methods ...