7 documents found, page 1 of 1
Combined use of chitosan and olfactory mucosa mesenchymal stem/stromal cells to...
Alvites, Rui D.; Branquinho, Mariana V.; Sousa, Ana C.; Amorim, Irina; Magalhães, Rui; João, Filipa; Almeida, Diogo; Amado, Sandra; Prada, JustinaPeripheral nerve injury remains a clinical challenge with severe physiological and functional consequences. Despite the existence of multiple possible therapeutic approaches, until now, there is no consensus regarding the advantages of each option or the best methodology in promoting nerve regeneration. Regenerative medicine is a promise to overcome this medical limitation, and in this work, chitosan nerve guid...
Combined Use of Chitosan and Olfactory Mucosa Mesenchymal Stem/Stromal Cells to...
Alvites, R. D.; Branquinho, Mariana V.; Sousa, Ana C.; Amorim, Irina; Magalhães, Rui; João, Filipa; Almeida, Diogo; Amado, Sandra; Prada, JustinaPeripheral nerve injury remains a clinical challenge with severe physiological and functional consequences. Despite the existence of multiple possible therapeutic approaches, until now, there is no consensus regarding the advantages of each option or the best methodology in promoting nerve regeneration. Regenerative medicine is a promise to overcome this medical limitation, and in this work, chitosan nerve guid...
Rat olfactory mucosa mesenchymal stem/stromal cells (om-mscs): a characterizati...
Alvites, Rui D.; Branquinho, Mariana V.; Caseiro, Ana R.; Amorim, Irina; Pedrosa, Sílvia Santos; Rêma, Alexandra; Faria, Fátima; Porto, BeatrizStem/stromal cell-based therapies are a branch of regenerative medicine and stand as an attractive option to promote the repair of damaged or dysfunctional tissues and organs. Olfactory mucosa mesenchymal stem/stromal cells have been regarded as a promising tool in regenerative therapies because of their several favorable properties such as multipotency, high proliferation rate, helpful location, and few associ...
Dynamic feet distance: a new functional assessment during treadmill locomotion ...
Diogo, Camila Cardoso; Costa, Luís Maltez da; Pereira, José Eduardo; Filipe, Vítor; Couto, Pedro Alexandre; Magalhães, Luís Gonzaga MendesOf all the detrimental effects of spinal cord injury (SCI), one of the most devastating is the disruption of the ability to perform functional movement. Very little is known on the recovery of hindlimb joint kinematics after clinically-relevant contusive thoracic lesion in experimental animal models. A new functional assessment instrument, the dynamic feet distance (DFD) was used to describe the distance betwee...
Evaluation of PVA biodegradable electric conductive membranes for nerve regener...
Ribeiro, Jorge; Caseiro, Ana Rita; Pereira, Tiago; Armada‐da‐Silva, Paulo Alexandre; Pires, Isabel; Prada, Justina; Irina, Amorim; Reis, Inês LealThe therapeutic effect of three polyvinyl alcohol (PVA) membranes loaded with electrically conductive materials - carbon nanotubes (PVA-CNTs) and polypyrrole (PVA-PPy) - were tested in vivo for neuro-muscular regeneration after an axonotmesis injury in the rat sciatic nerve. The membranes electrical conductivity measured was 1.5 ± 0.5 × 10-6 S/m, 579 ± 0.6 × 10-6 S/m, and 1837.5 ± 0.7 × 10-6 S/m, respectively. ...
Chitosan tubes of varying degrees of acetylation for bridging peripheral nerve ...
Haastert-Talinia, Kirsten; Geuna, Stefano; Dahlin, Lars B.; Meyer, Cora; Stenberg, Lena; Freier, Thomas; Heimann, Claudia; Barwig, ChristinaBiosynthetic nerve grafts are desired as alternative to autologous nerve grafts in peripheral nerve reconstruction. Artificial nerve conduits still have their limitations and are not widely accepted in the clinical setting. Here we report an analysis of fine-tuned chitosan tubes used to reconstruct 10 mm nerve defects in the adult rat. The chitosan tubes displayed low, medium and high degrees of acetylation (DA...
BIOHYBRID – Biohybrid templates for peripheral nerve regeneration
Grothe, Claudia; Haastert-Talini, K.; Freier, T.; Navarro, X.; Dahlin, L. B.; Salgado, A. J.; Rochkind, S.; Shahar, A.; Pinto, L. F.; Hildebrandt, M.[Excerpt] Peripheral nerve injuries represent a major cause for morbidity and disability in affected patients and cause substantial costs for society in a global perspective. It has been estimated that peripheral nerve injuries affect 2.8% of trauma patients,many of whom acquire life-long disability (Noble et al., 1998). With respect to an incidence of nerve injuries of 13.9/100,000 inhabitants per year (Asplun...