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Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist prido...

Geva, Michal; Gershoni-Emek, Noga; Naia, Luana; Ly, Philip; Mota, Sandra; Rego, Ana Cristina; Hayden, Michael R.; Levin, Leonard A.

Optic neuropathies such as glaucoma are characterized by retinal ganglion cell (RGC) degeneration and death. The sigma-1 receptor (S1R) is an attractive target for treating optic neuropathies as it is highly expressed in RGCs, and its absence causes retinal degeneration. Activation of the S1R exerts neuroprotective effects in models of retinal degeneration. Pridopidine is a highly selective and potent S1R agoni...

Date: 2021   |   Origin: Estudo Geral - Universidade de Coimbra
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