21 documents found, page 1 of 3
Validation of a Heart Failure Risk Score in a Cohort of Cardiac Resynchronizati...
Cardoso, I; Cunha, P; Laranjo, S; Grazina, A; Viegas, J; Portugal, G; Valente, B; Lousinha, A; Brás, P; Brás, M; Cruz Ferreira, R; Oliveira, MThe heart failure risk status (HFRS) is a validated dynamic tool for risk score prediction, based on the TriageHF™ algorithm (Medtronic, Minneapolis, MN, USA), for the occurrence of a heart failure (HF) event in the 30 days following a remote monitoring (RM) transmission. The aim of this study was to evaluate the accuracy of the HFRS in predicting an unplanned hospital admission due to HF decompensation in a re...
A Ring With Endocarditis: an Unfortunate Marriage
Castelo, A; Cardoso, I; Magalhães, M; Timóteo, AT; Galrinho, A
Microvascular Dysfunction Is Associated With Impaired Myocardial Work in Obstru...
Garcia Brás, P; Aguiar Rosa, S; Cardoso, I; Branco, L; Galrinho, A; Valentim Gonçalves, A; Thomas, B; Viegas, JM; Fiarresga, A; Branco, G; Pereira, RBackground Two-dimensional speckle tracking echocardiography has been shown to correlate with microvascular dysfunction, a hallmark of hypertrophic cardiomyopathy (HCM). We hypothesized that there is an association between myocardial work and left ventricular ischemia, with incremental value to global longitudinal strain, in patients with HCM. Methods and Results We performed a prospective assessment of patient...
Popeye Deformity: a Red Flag for Wild-Type Transthyretin Amyloidosis
Viegas, JM; Brás, P; Cardoso, I; Aguiar Rosa, S
Myocardial Work Brings New Insights into Left Ventricular Remodelling in Cardio...
Vaz Ferreira, V; Mano, T; Cardoso, I; Coutinho Cruz, M; Branco, LM; Almeida-Morais, L; Timóteo, AT; Galrinho, A; Castelo, A; Garcia Brás, P; Simão, DSerial transthoracic echocardiographic (TTE) assessment of 2D left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) are the gold standard screening methods for cancer therapeutics-related cardiac dysfunction (CTRCD). Non-invasive left ventricular (LV) pressure-strain loop (PSL) provides a novel method of quantifying myocardial work (MW) with potential advantages to evaluate the impact o...
Blunted Coronary Flow Velocity Reserve is Associated With Impairment in Systoli...
Aguiar Rosa, S; Rocha Lopes, L; Branco, L; Galrinho, A; Fiarresga, A; Thomas, B; Brás, P; Gonçalves, A; Cardoso, I; Papoila, A; Alves, M; Rio, PBackground Coronary microvascular dysfunction constitutes an important pathophysiological feature in hypertrophic cardiomyopathy (HCM). We aimed to assess the association between impaired coronary flow velocity reserve (CFVR) and ventricular systolic function and functional capacity. Methods Eighty-three patients with HCM were enrolled in this prospective cohort study. Patients underwent echocardiogram to evalu...
Associations Between Perfusion Defects, Tissue Changes and Myocardial Deformati...
Brás, P; Aguiar Rosa, S; Thomas, B; Fiarresga, A; Cardoso, I; Pereira, R; Branco, G; Cruz, I; Baquero, L; Cruz Ferreira, R; Mota Carmo, MBackground: Microvascular dysfunction is an often overlooked feature of hypertrophic cardiomyopathy (HCM). Our aim was to assess the association between microvascular dysfunction, wall thickness, tissue characteristics and myocardial deformation in HCM patients, by analyzing individual myocardial segments. Methods: Prospective assessment including cardiac magnetic resonance to assess wall thickness, T1 and T2 m...
Coronary Microvascular Dysfunction in Cardio-Oncology
Cardoso, I; Mano, T
Dynamic interactions and Ca(2+)-binding modulate the holdase-type chaperone act...
Moreira, GG; Cantrelle, FX; Quezada, A; Carvalho, FS; Cristóvão, JS; Sengupta, U; Puangmalai, N; Carapeto, AP; Rodrigues, MS; Cardoso, I; Fritz, GThe microtubule-associated protein tau is implicated in the formation of oligomers and fibrillar aggregates that evade proteostasis control and spread from cell-to-cell. Tau pathology is accompanied by sustained neuroinflammation and, while the release of alarmin mediators aggravates disease at late stages, early inflammatory responses encompass protective functions. This is the case of the Ca2+-binding S100B p...
Neuroprotection in early stages of Alzheimer’s disease is promoted by transthyr...
Gião, T; Saavedra, J; Vieira, JR; Pinto, MT; Arsequell, G; Cardoso, IBackground: While still controversial, it has been demonstrated that vascular defects can precede the onset of other AD hallmarks features, making it an important therapeutic target. Given that the protein transthyretin (TTR) has been established as neuroprotective in AD, here we investigated the influence of TTR in the vasculature. Methods: We evaluated the thickness of the basement membrane and the length of ...