2 documents found, page 1 of 1
Exploring new antiviral targets for influenza and COVID-19: Mapping promising h...
Figueiredo-Nunes, Inês; Trigueiro-Louro, João; Rebelo-de-Andrade, HelenaInfluenza and COVID-19 are infectious respiratory diseases that represent a major concern to public health with social and economic impact worldwide, for which the available therapeutic options are not satisfactory. The RdRp has a central role in viral replication and thus represents a major target for the development of antiviral approaches. In this study, we focused on Influenza A virus PB1 polymerase protein...
Unlocking COVID therapeutic targets: A structure-based rationale against SARS-C...
Trigueiro-Louro, João; Correia, Vanessa; Figueiredo-Nunes, Inês; Gíria, Marta; Rebelo-de-Andrade, HelenaThere are no approved target therapeutics against SARS-CoV-2 or other beta-CoVs. The beta-CoV Spike protein is a promising target considering the critical role in viral infection and pathogenesis and its surface exposed features. We performed a structure-based strategy targeting highly conserved druggable regions resulting from a comprehensive large-scale sequence analysis and structural characterization of Spi...