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MERVL/Zscan4 network activation results in transient genome-wide DNA demethylat...

Eckersley-Maslin, Mélanie A.; Svensson, Valentine; Krueger, Christel; Stubbs, Thomas M.; Giehr, Pascal; Krueger, Felix; Miragaia, Ricardo Júdice

Mouse embryonic stem cells are dynamic and heterogeneous. For example, rare cells cycle through a state characterized by decondensed chromatin and expression of transcripts, including the Zscan4 cluster and MERVL endogenous retrovirus, which are usually restricted to preimplantation embryos. Here, we further characterize the dynamics and consequences of this transient cell state. Single-cell transcriptomics ide...

Date: 2016   |   Origin: RepositóriUM - Universidade do Minho
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