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MicroRNA-mediated control of mesenchymal stem/stromal cell senescence: A compar...

Giestinhas, Andrea; Moura, Sara Reis; Silva, Elsa; Nascimento, Diana; Almeida, Maria Inês

Osteoarthritis is a growing health problem, aggravated by aging. Mesenchymal stem/stromal cells (MSCs) emerged as a promising cell-based therapy for this disease. However, in vitro expansion of MSCs can result in cell senescence. MicroRNAs (miRNAs) are key regulators of senescence pathways, making them attractive targets to decrease senescence. This work aims to identify senescence-related miRNAs, with the long...

Date: 2025   |   Origin: Repositório Científico do Instituto Politécnico do Porto
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