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Impact of Plasma-Lyte pH 7.4 on acid-base status and hemodynamics in a model of...
Noritomi, Danilo Teixeira; Pereira, Adriano José; Bugano, Diogo Diniz Gomes; Rehder, Paulo Sergio; Silva, EliézerOBJECTIVE: Intravenous infusion of crystalloid solutions is a cornerstone of the treatment of hemorrhagic shock. However, crystalloid solutions can have variable metabolic acid-base effects, perpetuating or even aggravating shock-induced metabolic acidosis. The aim of this study was to compare, in a controlled volume-driven porcine model of hemorrhagic shock, the effects of three different crystalloid solutions...
Sepsis: from bench to bedside
Silva, Eliézer; Passos, Rogério Da Hora; Ferri, Maurício Beller; Figueiredo, Luiz Francisco Poli deSepsis is a syndrome related to severe infections. It is defined as the systemic host response to microorganisms in previously sterile tissues and is characterized by end-organ dysfunction away from the primary site of infection. The normal host response to infection is complex and aims to identify and control pathogen invasion, as well as to start immediate tissue repair. Both the cellular and humoral immune s...