10 documents found, page 1 of 1
Antibiotic heteroresistance and persistence: an additional aid in hospital acqu...
Geraldes, Catarina; Tavares, Luís; Gil, Solange; Oliveira, ManuelaEnterococcus, particularly E. faecium and E. faecalis, are responsible for many hospital-acquired infections. With their intrinsic antibiotic resistance and ability to form biofilms, enterococcal infections are already challenging to manage. However, when heterogenous populations are present, such as those exhibiting heteroresistance and persistence, the complexity of these infections increases exponentially no...
Rabbit derived VL single-domains as promising scaffolds to generate antibody–dr...
André, Ana; Dias, Joana N. R.; Aguiar, Sandra I; Nogueira, Sara; Bule, Pedro; Carvalho, Joana; António, João P. M.; Cavaco, Marco; Neves, VeraAntibody-drug conjugates (ADCs) are among the fastest-growing classes of therapeutics in oncology. Although ADCs are in the spotlight, they still present significant engineering challenges. Therefore, there is an urgent need to develop more stable and effective ADCs. Most rabbit light chains have an extra disulfide bridge, that links the variable and constant domains, between Cys80 and Cys171, which is not foun...
Diagnostic approach and grading scheme for canine allergic conjunctivitis
Delgado, Esmeralda; Gomes, Érica; Gil, Solange; Lourenço, Ana MafaldaABSTRACT: Background: In humans, allergic conjunctivitis is a well described disease. In contrast, allergic conjunctivitis has not received much attention from the veterinary community so far. Canine allergic conjunctivitis (cAC) is one of the possible manifestations associated with canine atopic dermatitis (cAD), being often underdiagnosed and undertreated. Our aim is to contribute to disease characterization ...
Characterization of the canine CD20 as a therapeutic target for comparative pas...
Dias, Joana N. R.; Almeida, André; S. André, Ana; Aguiar, Sandra I; Bule, Pedro; Nogueira, Sara; Oliveira, Soraia S; Carrapiço, Belmira; Gil, SolangeAnti-CD20 therapies have revolutionized the treatment of B-cell malignancies. Despite these advances, relapsed and refractory disease remains a major treatment challenge. The optimization of CD20-targeted immunotherapies is considered a promising strategy to improve current therapies. However, research has been limited by the scarcity of preclinical models that recapitulate the complex interaction between the i...
A 5-year retrospective study of canine and feline patients referred to an isola...
Paulo, Catarina; Machado, Inês; Carvalho, Helena; Gomes, Joana; Mota, Ana Deodato; Tavares, Luis; Almeida, Virgilio; Gil, SolangeBackground: Referral of cases is becoming more and more frequent in companion animal practice. The Infectious Diseases Isolation Unit (IDIU) admits first opinion, second opinion and referred patients with a confirmed infectious disease (ID) or a clinically suspected ID that is awaiting laboratory diagnosis. The primary aims of this study were to describe the annual number and characteristics of patients referre...
Controlling bacteriological contamination of environmental surfaces at the biol...
Verdial, C; Carneiro, Carla; Machado, Inês; Tavares, Luis; Almeida, Virgilio; Oliveira, Manuela; Gil, SolangeBackground: The Biological Isolation and Containment Unit (BICU) is a subunit of the Teaching Hospital of the Faculty of Veterinary Medicine of the University of Lisbon, Portugal, for the admission of animals with confirmed infectious diseases or under clinical suspicion and waiting for a diagnosis. As a high-risk environment for the transmission of infectious agents, it is extremely important to implement prog...
Evaluation of a biocide used in the Biological Isolation and Containment Unit o...
GERALDES, CATARINA; Verdial, Cláudia; Cunha, Eva; Almeida, Virgilio; Tavares, Luis; Oliveira, Manuela; Gil, SolangeHospital-acquired infections (HAIs) are a rising problem worldwide, and the best way of coping with them is through infection tracking and surveillance systems, combined with prevention strategies, namely efficient disinfection protocols, that employ various biocides. However, increasing reports about reductions in biocide susceptibility and the development of cross-resistance to antimicrobials emphasize the ne...
Canine parvovirus : a predicting canine model for sepsis
Alves, F.; Prata, S.; Nunes, Telmo; Gomes, J.; Aguiar, Sandra; Aires da Silva, Frederico; Tavares, Luis; Almeida, Virgilio; Gil, SolangeBackground: Sepsis is a severe condition associated with high prevalence and mortality rates. Parvovirus enteritis is a predisposing factor for sepsis, as it promotes intestinal bacterial translocation and severe immunosuppression. This makes dogs infected by parvovirus a suitable study population as far as sepsis is concerned. The main objective of the present study was to evaluate the differences between two ...
Relevance of feline interferon omega for clinical improvement and reduction of ...
Gil, Solange; Leal, Rodolfo O.; Duarte, Ana; McGahie, David; Sepúlveda, Nuno; Siborro, Inês; Cravo, Joana; Cartaxeiro, Clara; Tavares, Luís M.Feline Immnunodeficiency (FIV) and Feline Leukemia (FeLV) viruses are common infectious agents in stray cats and shelter environments. Recombinant feline interferon-x (rFeIFNx) has shown an antiviral action not only against FIV and FeLV but also against herpesvirus (FHV-1) and calicivirus (FCV). Sixteen naturally infected FIV/FeLV cats were followed during rFeIFNx therapy in order to monitor clinical signs and ...
The use of oral recombinant feline interferon omega in two cats with type II di...
Leal, Rodolfo O.; Gil, Solange; Brito, Maria T. V.; McGahie, David; Niza, Maria M. R. E.; Tavares, LuísFeline Chronic Gingivostomatitis Syndrome (FCGS) is a common disease in clinical practice. Among the therapeutic options available, long-acting corticosteroids are frequently used due to their anti-inflammatory and immunosuppressive properties. Although they may improve the clinical symptoms, they can lead to a progressive form of the disease that becomes refractory to treatment. Furthermore, their direct relat...