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Transthyretin Amyloidosis: Chaperone Concentration Changes and Increased Proteo...

Costa, G; Ribeiro-Silva, C; Ribeiro, R; Gilberto, S; Gomes, R; Ferreira, A; Mateus, E; Barroso, E; Coelho, A; Ponces Freire, A; Cordeiro, C

Transthyretin amyloidosis is a conformational pathology characterized by the extracellular formation of amyloid deposits and the progressive impairment of the peripheral nervous system. Point mutations in this tetrameric plasma protein decrease its stability and are linked to disease onset and progression. Since non-mutated transthyretin also forms amyloid in systemic senile amyloidosis and some mutation bearer...

Date: 2015   |   Origin: Repositório do Centro Hospitalar de Lisboa Central, EPE
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