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Computationally-designed miniproteins showing neutralization activity against S...
Moreira, Pedro Daniel Martins; Parada, Mariana; Fernandes, Bárbara; Buga, Carolina C.; Teixeira, Rita I.; Oliveira, Christine; Buckley, Stephen MichaelAs the COVID-19 pandemic demonstrated, the need for robust antiviral therapies against SARS-CoV-2 remains substantial. A promising strategy to meet this demand is through the development of proteins tailored for enhanced binding affinity to crucial viral targets, such as epitopes located on their fusion proteins. Among these targets is the Spike proteins receptor binding domain (RBD), which interacts with the h...
Computational design of antiviral biologics targeting Zika virus envelope protein
Pereira, Maria Benedita; Moreira, Pedro Daniel Martins; Teixeira, Rita I.; Soares, Cláudio M.; Lousa, DianaIn the past two decades, the world has struggled with recurrent viral outbreaks, with viruses from diverse families demonstrating pandemic and epidemic potential. One of those viruses is the Zika virus. Despite disease cases having declined globally after 2017, Zika virus transmission persists at low levels in regions like the Americas and a total of 89 countries and territories have reported evidence of Zika v...
Implementing a webserver for managing and detecting viral fusion proteins
Moreira, Pedro Daniel MartinsViral fusion proteins are essential to allow enveloped viruses (such as Influenza, Dengue, HIV and SARS-CoV-2) to enter their hosts’ cells, in a mechanism referred to as membrane fusion. This makes these proteins (with special relevance to their fusion peptides, the com ponent of the protein that can insert into the host’s membrane by itself) interesting potential therapeutic targets for preventing or treating ...