3 documents found, page 1 of 1
Efficacy and safety of pharmacological interventions for managing sickle cell d...
Tonin, FS; Ginete, C; Fernandez-Llimos, F; Ferreira, J; Delgadinho, M; Brito, MIntroductionSickle cell disease (SCD), an inherited haemoglobinopathy, has important impact on morbidity and mortality, especially in paediatrics. Previous systematic reviews are limited to adult patients or focused only on few therapies. We aim to synthesise the evidence on efficacy and safety of pharmacological interventions for managing SCD in children and adolescents.Methods and analysisThis systematic revi...
Efficacy and safety of pharmacological interventions for managing sickle cell d...
Tonin, FS; Ginete, C; Ferreira, J; Delgadinho, M; Santos, B; Fernandez-Llimos, F; Brito, MThis study aimed to synthesize the evidence on the effects of disease-modifying agents for managing sickle cell disease (SCD) in children and adolescents by means of a systematic review with network meta-analyses, surface under the cumulative ranking curve (SUCRA) and stochastic multicriteria acceptability analyses (SMAA) (CRD42022328471). Eightteen randomized controlled trials (hydroxyurea [n = 7], l-arginine ...
Identification of Genetic Variants in 65 Obesity Related Genes in a Cohort of P...
Ginete, C; Serrasqueiro, B; Silva-Nunes, J; Veiga, L; Brito, MObesity is a major public health problem, which has a strong genetic component that interplays with environmental factors. Several genes are known to be implicated in the regulation of body weight. The identification of alleles that can be associated with obesity is a key element to control this pandemic. On the basis of a Portuguese population, 65 obesity-related genes are sequenced using Next-Generation Seque...