51 documents found, page 1 of 6
Treating sickle cell disease in resource-limited sub-Saharan Africa: recent str...
Brito, Miguel; Ginete, Catarina; Ofakunrin, Akinyemi; Diaku-Akinwumi, Ijeoma; Inusa, Baba PsalmIntroduction: The management of Sickle cell disease (SCD) in sub-Saharan Africa (SSA) suffers from the lack of universal infant and population screening, inadequate access to standard treatment, and poor public health prioritization amidst unstable political systems. Areas covered: The state of evidence-based management of SCD in SSA was investigated, including the sustainability of international funding agenci...
DNA methyltransferase expression (DNMT1, DNMT3a, and DNMT3b) as a potential bio...
Camacho, Pedro; Ribeiro, Edna; Pereira, Bruno; Nascimento, João; Rosa, Paulo Caldeira; Henriques, José; Barrão, Sandra; Sadio, Silvia; Quendera, BrunoBackground/Objectives: Age-related macular degeneration (AMD) is a global cause of vision loss, with limited therapeutic options highlighting the need for effective biomarkers. This study aimed to characterize plasma DNA methyltransferase expression (DNMT1, DNMT3A, and DNMT3B) in AMD patients and explore divergent expression patterns across different stages of AMD. Methods: Thirty-eight AMD patients were prospe...
Treating sickle cell disease in resource-limited sub-Saharan Africa: recent str...
Brito, Miguel; Ginete, Catarina; Ofakunrin, Akinyemi; Diaku-Akinwumi, Ijeoma; Inusa, Baba Psalm DuniyaIntroduction: The management of Sickle cell disease (SCD) in sub-Saharan Africa (SSA) suffers from the lack of universal infant and population screening, inadequate access to standard treatment and poor public health prioritization amidst unstable political systems. Areas covered: The state of evidencebased management of SCD in SSA was investigated including sustainability of international funding agencies. Exp...
Characterization of a cohort of Angolan children with sickle cell anemia treate...
Santos, Brígida; Ginete, Catarina; Gonçalves, Elisângela; Delgadinho, Mariana; Miranda, Armandina; Faustino, Paula; Arez, Ana Paula; Brito, MiguelBackground: Sickle Cell Anemia (SCA) is a monogenic disease, although its severity and response to treatment are very heterogeneous. Objectives: This study aims to characterize a cohort of Angolan children with SCA and evaluate their response to hydroxyurea (HU) treatment and the potential side effects and toxicity. Methods: The study enrolled 215 patients between 3 and 12 years old before and after the adminis...
A implementação de um rastreio neonatal de doença das células falciformes em An...
Brito, Miguel; Ginete, Catarina; Inusa, Baba; Mendes, Manuela; Vasconcelos, Jocelyne Neto; Veiga, LuisaIntrodução: A doença das células falciformes (DCF) é uma doença hereditária severa, com uma incidência especialmente elevada na África subsariana, sendo responsável por 50% da mortalidade em crianças com menos de 5 anos. A prevalência desta doença genética em Angola ronda os 2%, sendo a doença genética mais frequentes no mundo. A identificação da doença à nascença permite o seguimento das crianças em consultas ...
Learner-low dose aspirin preterm trial (Angola) – Low dose aspirin in pregnant ...
Brito, Miguel; Ginete, Catarina; Gomes, Tatiana; Pitangueira, Helena; Mendes, Manuela; Furtado, Ana; Alves, Ligia; Simão, Fernanda; Gonçalves, MauerSickle Cell Disease (SCD) is marked by episodes of acute vaso-occlusive crises, severe anemia, acute chest syndrome, multi-organ damage and stroke, among others. Pregnancy in these patients is associated with an increased risk of adverse outcomes, such as intrauterine growth restriction, perinatal and maternal mortality, low birth weight, eclampsia, pre-eclampsia, and stroke. Therefore, increasing the surveilla...
Differential expression of adhesion molecules in sickle cell anemia and gut mic...
Delgadinho, Mariana; Veiga, Luisa; Ginete, Catarina; Santos, Brígida; Miranda, Armandina; Vasconcelos, Jocelyne Neto de; Brito, MiguelSickle cell anemia (SCA) causes a long-standing vascular inflammation state, leading to endothelial dysfunction and chronic overexpression of several adhesion molecules, which contributes to acute and constant vaso-occlusive (VOC) episodes. It has been demonstrated that hydroxyurea (HU) can reduce VOC events, organ damage, blood transfusions, and even the adhesion properties to endothelial cells of SCA subjects...
Towards an integrated approach on occupational health to tackle COVID-19 pandemic
Ribeiro, Edna; Oliveira, Ketlyn; Dias, Marta; Gomes, Bianca; Pimenta, Raquel; Delgadinho, Mariana; Ginete, Catarina; Abreu, RenatoBackground: Serological screening is crucial for the prevention of infection, ensuring the maintenance of the worker’s health, and thus promoting occupational health. It was reported that SARS-CoV-2 can survive in aerosols and on dry surfaces for several days to weeks. Objectives: We aimed to apply an integrated approach to Occupational Health to tackle the COVID-19 pandemic. Materials and methods: We performed...
The interplay between HPV, other sexually transmissible infections and genital ...
Gonçalves-Nobre, J. Guilherme; Matos, Andreia; Carreira, Mariana; Santos, Ana Carolina; Veiga, Luisa; Ginete, Catarina; Brito, Miguel; Pires, MarinaBackground: The importance of Cervicovaginal Microbiota in protecting against infections (such as HPV) is already well established, namely through Lactobacillus spp., as well as the mechanism through which HPV leads to Cervical Neoplasia. However, it is not possible to classify HPV as a complete carcinogen. Thus, the importance of exploring Cervicovaginal dysbiosis to decipher this interaction with HPV takes on...
Sickle cell disease and gut health: the influence of intestinal parasites and t...
Delgadinho, Mariana; Ginete, Catarina; Santos, Brígida; Vasconcelos, Jocelyne Neto; Arez, Ana Paula; Brito, MiguelParasitic infections are a common problem in developing countries and can intensify morbidity in patients with sickle cell disease (SCD), increasing the severity of anemia and the need for transfusions. It has been demonstrated that both helminths and protozoa can affect gut microbiome composition. On the other hand, the presence of specific bacterial communities can also influence parasite establishment. Consi...