39 documents found, page 1 of 4
The Impact of a Western Diet and Resistance Training in a Rat Model of Mammary ...
Silva, Jessica; Ferreira, Rita; Neuparth, Maria J.; Seixas, Fernanda; Ginja, Mário; Pires, Maria J.; Faustino-Rocha, Ana I.; Duarte, José AlbertoThis study aimed to investigate the impact of a Western diet and resistance training on cardiac remodeling in a rat model of chemically induced mammary cancer. Fifty-six female Wistar rats were randomly assigned to one of eight experimental groups, evaluating the impact of Western and standard diets, exercise and sedentarism, and the induction of mammary cancer. Mammary cancer was induced via the intraperitonea...
Realistic Aspects of Cardiac Ultrasound in Rats: Practical Tips for Improved Ex...
Silva, Jessica; Ginja, Mário; Oliveira, Paula A.; Duarte, José Alberto; Faustino-Rocha, AnaEchocardiography is a reliable and non-invasive method for assessing cardiac structure and function in both clinical and experimental settings, offering valuable insights into disease progression and treatment efficacy. The successful application of echocardiography in murine models of disease has enabled the evaluation of disease severity, drug testing, and continuous monitoring of cardiac function in these an...
An Input in the Asian Wasp Nest (AWN) Study
Pinto, Jorge; Ginja, Mário; Nepomuceno, Miguel C. S.; Pereira, SandraThe Asian Wasp Nest (AWN) is an impressive and robust natural construction built by an insect. The building process occurs during spring and summer. This type of nest is not reused. The scale size between the Asian wasp and the AWN is substantial. In Portugal, we can find AWN on trees, roofs, balconies, chimneys, and other possibilities. When the AWN is built on trees, the tree's branches work as support. The c...
Investigating the Architecture and Characteristics of Asian Hornet Nests: A Bio...
Sedira, Naim; Pinto, Jorge; Ginja, Mário; Gomes, Ana; Nepomuceno, Miguel C. S.; Pereira, SandraThis study investigates the internal architecture of Asian hornet nests (AHNs) using advanced imaging techniques, such as CT scanning and X-ray radiography, to understand their construction and function. The primary objective and significance of this study centre on drawing inspiration from the creative way Asian hornets construct their nests, with a particular focus on the architecture, design, functionality, ...
Ultrasonographic follow-up of the multistep protocol for prostate cancer induct...
Faustino-Rocha, Ana Faustino; Seixas, Fernanda; Ferreira, Rita; Silva, Jessica; Fardilha, Margarida; Oliveira, Paula Alexandra; Ginja, MárioAim: This work intended to improve the knowledge of the rat model of prostate cancer (PCa) by ultrasonographic monitoring. Materials and Methods: Male Wistar rats were divided into control (n=8) and PCa (n=14) groups. PCa development was induced in the PCa group through the sequential administration of the anti-androgenic drug flutamide, testosterone propionate and the carcinogenic N-methyl-N-nitrosourea. The p...
Rat prostate: practical tips for ultrasonographic monitoring
Faustino-Rocha, Ana Isabel; Ferreira, Rita; Pires, Maria João; Fardilha, Margarida; Oliveira, Paula Alexandra; Ginja, MárioBackground: Prostate is the largest accessory gland of the male reproductive tract. The prostate of men over 40 years- old is frequently affected by several pathologies, like benign prostate hyperplasia and cancer. Rats have been used as model to study prostate cancer. This study intended to address the usefulness of ultrasonography for rat prostate monitoring. Materials and Methods: Eight male Wistar Unilever ...
Immunology and mammary cancer development: addressing the role of mast cells
Faustino-Rocha, Ana Isabel; Oliveira, Paula Alexandra; Gama, Adelina; Ferreira, Rita; Ginja, MárioBackground: Mammary cancer is one of the most frequent cancers worldwide. Mast cells are among the cells of tumor microenvironment and have been associated with increased angiogenesis and poor prognosis. Despite this, the role of mast cells on mammary cancer is not fully elucidated. In this way, this work studied the role of mast cells in a rat model of mammary cancer chemically-induced. Materials and Methods: ...
Immunology and mammary cancer development: addressing the role of mast cells
Faustino-Rocha, Ana Isabel; Oliveira, Paula Alexandra; Gama, Adelina; Ferreira, Rita; Ginja, MárioBackground: Mammary cancer is one of the most frequent cancers worldwide. Mast cells are among the cells of tumor microenvironment and have been associated with increased angiogenesis and poor prognosis. Despite this, the role of mast cells on mammary cancer is not fully elucidated. In this way, this work studied the role of mast cells in a rat model of mammary cancer chemically-induced. Material and methods: A...
N-methyl-N-nitrosourea as a mammary carcinogen: practical application
Faustino-Rocha, Ana Isabel; Oliveira, Paula Alexandra; Gama, Adelina; Ferreira, Rita; Ginja, MárioIntroduction: N-methyl-N-nitrosourea (MNU) is the oldest member of the nitroso compounds. It is considered a complete, potent and direct alkylating compound, able to alkylate the DNA without metabolic activation. The administration of chemical carcinogens is one of the most frequently used methods to induce tumors’ development in laboratory animals. The target organ depends on the animals’ species, strain and a...
N-methyl-N-nitrosourea as a mammary carcinogen: practical application
Faustino-Rocha, Ana Isabel; Oliveira, Paula Alexandra; Gama, Adelina; Ferreira, Rita; Ginja, Máriontroduction: N-methyl-N-nitrosourea (MNU) is the oldest member of the nitroso compounds. It is considered a complete, potent and direct alkylating compound, able to alkylate the DNA without metabolic activation. The administration of chemical carcinogens is one of the most frequently used methods to induce tumors’ development in laboratory animals. The target organ depends on the animals’ species, strain and ag...