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Ischaemia alters the effects of cardiomyocyte-derived extracellular vesicles on...

We thank Dr Nuno Alves (Cardiology Department, CHUC‐HG) who performed the collection of human blood samples and Doctor Francisco Caramelo (iCBR/FMUC) for helping with the statistical analysis. This work was supported by the European Regional Development Fund (ERDF) through the Operational Program for Competitiveness Factors (COMPETE) [under the projects PAC “NETDIAMOND” POCI‐01‐0145‐FEDER‐016385; HealthyAging20...

Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angi...

Funding Information: This work was supported by European Regional Development Fund (FEDER) through the Operational Program for Competitiveness Factors (COMPETE) [HealthyAging2020 CENTRO-01-0145-FEDER-000012-N2323, POCI-01-0145-FEDER-016385, POCI-01-0145-FEDER-007440 to CNC.IBILI, POCI-01-0145-FEDER-007274 to i3S/INEB and NORTE-01-0145-FEDER-000012 to T.L.L.]; national funds through the Portuguese Foundation for...

Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the an...

Extracellular vesicles (EVs) are major conveyors of biological information, mediating local and systemic cell-to-cell communication under physiological and pathological conditions. These endogenous vesicles have been recognized as prominent drug delivery vehicles of several therapeutic cargoes, including doxorubicin (dox), presenting major advantages over the classical approaches. Although dox is one of the mos...

Erratum

K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chape...

We thank Dr. Ana Maria Cuervo for providing the shRNA against Lamp2a and Dr. Cam Patterson for the wild-type and mutant STUB1 constructs. This work was supported by grants from the Portuguese Foundation for Science and Technology (FCT), PTDC/SAU-ORG/113542/2009, PTDC/SAU-ORG/118694/2010, PEST-C/SAU/UI3282/2011-COMPETE and UID/NEU/04539/2013 from FCT.; Chaperone-Mediated Autophagy is a selective form of autophag...

STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy

The transcription factor HI F1 is mostly regulated by the oxygen-dependent proteasomal degradation of the labile subunit HI F1A. Recent data showed degradation of HI F1A in the lysosome through chaperone-mediated autophagy (CMA). However the molecular mechanism involved has not been elucidated. This study shows that the KFER Q-like motif, that has been identified in all CMA substrates, is required to mediate th...