8 documents found, page 1 of 1
Validation of the Therapeutic Self-Care Scale-European Portuguese Version in Pr...
Cardoso, Ana Filipa; Queirós, Paulo; Amaral, António Salgueiro; Fontes-Ribeiro, Carlos; Rosa, Amorim; Cruz, Rui; Neto, Matilde AgostinhoSelf-care is an important nursing-sensitive outcome. Reliable and valid measures are needed for therapeutic self-care assessment that may inform the development and evaluation of individualized nursing interventions co-created with type 2 diabetes mellitus (T2DM) adults. The therapeutic self-care scale European Portuguese version (TSCS-EPV) is a validated generic measure that may be used to assess self-care in ...
Predictors of physical activity promotion in clinical practice: a cross-section...
Silva, Catarina Santos; Mendes, Romeu; Godinho, Cristina; Monteiro-Pereira, Ana; Pimenta-Ribeiro, Jaime; Martins, Helena Silva; Brito, JoãoBackground: Physical activity is a major determinant of physical and mental health. International recommendations identify health professionals as pivotal agents to tackle physical inactivity. This study sought to characterize medical doctors’ clinical practices concerning the promotion of patients’ physical activity, while also exploring potential predictors of the frequency and content of these practices, inc...
Cellular and Molecular Mechanisms Mediating Methylmercury Neurotoxicity and Neu...
Novo, João P.; Martins, Beatriz; Raposo, Ramon S.; Pereira, Frederico C.; Oriá, Reinaldo B; Malva, João O.; Fontes-Ribeiro, CarlosMethylmercury (MeHg) toxicity is a major environmental concern. In the aquatic reservoir, MeHg bioaccumulates along the food chain until it is consumed by riverine populations. There has been much interest in the neurotoxicity of MeHg due to recent environmental disasters. Studies have also addressed the implications of long-term MeHg exposure for humans. The central nervous system is particularly susceptible t...
A novel semi-solid pill for stress-free voluntary oral drug administration in e...
Viana, Sofia; Martins, B.; Nunes, S.; Palavra, F.; Preguiça, I.; Alves, A.; Nóbrega, C.; Fernandes, R.; Silva, S.; Barbosa Moreira, Zélia; Lima, D.L.D.During compound screening and drug development, long-term oral drug administration to experimental rodents is often required. Oral gavage, a straightforward drug dosing technique, is not suitable for extended treatments considering the recurrent traumatic complications (gastroesophageal injury) and physiological distress (corticosterone levels alterations) that frequently bias experimental design outcomes. Thes...
Region-specific control of microglia by adenosine A2A receptors: uncoupling anx...
Duarte, Joana Mendes; Gaspar, Rita; Caetano, Liliana; Patrício, Patrícia; Cunha, Carina Isabel Soares; Pinheiro, António Maria Restolho MateusEpidemiologic studies have provided compelling evidence that prenatal stress, through excessive maternal glucocorticoids exposure, is associated with psychiatric disorders later in life. We have recently reported that anxiety associated with prenatal exposure to dexamethasone (DEX, a synthetic glucocorticoid) correlates with a gender-specific remodeling of microglia in the medial prefrontal cortex (mPFC), a cor...
Pharmacovigilance in Portugal: Activity of the Central Pharmacovigilance Unit
Batel-Marques, Francisco; Mendes, Diogo; Alves, Carlos; Penedones, Ana; Dias, Patricia; Martins, Angelina; Santiago, Luiz Miguel; Fontes-Ribeiro, CarlosIntroduction: The aim of this study was to characterize the spontaneous reports of adverse events that were received by the Central Portugal Regional Pharmacovigilance Unit.Material and Methods: Spontaneous reports received between 01/2001 and 12/2013 were considered. The annual reporting ratios were estimated. The cases were characterized according to their seriousness, previous description, causality assessme...
Methamphetamine decreases dentate gyrus stem cell self-renewal and shifts the d...
Baptista, Sofia; Lasgi, Charlène; Benstaali, Caroline; Milhazes, Nuno; Borges, Fernanda; Fontes-Ribeiro, Carlos; Agasse, Fabienne; Silva, Ana PaulaMethamphetamine (METH) is a highly addictive psychostimulant drug of abuse that negatively interferes with neurogenesis. In fact, we have previously shown that METH triggers stem/progenitor cell death and decreases neuronal differentiation in the dentate gyrus (DG). Still, little is known regarding its effect on DG stem cell properties. Herein, we investigate the impact of METH on mice DG stem/progenitor cell s...
Relative bioavailability and bioquivalence of three different oral formulations...
Nunes, Teresa; Falcão, Amílcar; Almeida, Luís; Lima, Ricardo; Tavares, Susana; Neta, Carla; Fontes-Ribeiro, Carlos; Macedo, TiceAES Proceedings of the Annual Meeting of the American Epilepsy Society; To investigate the bioavailability and bioequivalence of three formulations of eslicarbazepine acetate: 50 mg/mL oral suspension (Test 1), 200 mg tablets (Test 2) and 800 mg tablets (Reference)