5 documents found, page 1 of 1
Resistance of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braz...
Giudice, Ângela; Camada, Ilza; Leopoldo, Paulo de Tarso Gonçalves; Pereira, Júlia M. B.; Rilley, Lee; Wilson, Mary; Ho, JohnBACKGROUND: Nitric oxide (NO•) plays a pivotal role as a leishmanicidal agent in mouse macrophages. NO• resistant Escherichia coli and Mycobacterium tuberculosis have been associated with a severe outcome of these diseases. METHODS: In this study we evaluated the in vitro toxicity of nitric oxide for the promastigote stages of Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis parasites, ...
Differential effects of antigens from L. braziliensis isolates from disseminate...
Leopoldo, Paulo de Tarso Gonçalves; Almeida, Roque Pacheco de; Schriefer, Albert; Giudice, Ângela; Jesus, Amélia Maria Ribeiro de; Ho, JohnBACKGROUND: Disseminated leishmaniasis is an emerging infectious disease, mostly due to L. braziliensis, which has clinical and histopathological features distinct from cutaneous leishmaniasis. METHODS: In the current study we evaluated the in vitro production of the cytokines IFN-γ, TNF-α, IL-5 and IL-10 by peripheral blood mononuclear cells (PBMC) from 15 disseminated leishmaniasis and 24 cutaneous leishmania...
BALB/c mice infected with antimony treatment refractory isolate of Leishmania b...
Costa, Diego Luis; Carregaro, Vanessa; Lima Júnior, Djalma Souza de; Silva, Neide Maria da; Milanezi, Cristiane MariaThis study was supported by the Brazilian National Research Council (CNPq) and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). JSS, EMC, ARJ and RPA are investigators from the Brazilian National Research Council (CNPq). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.; BACKGROUND: Leishmania braziliensis is the main caus...
Resistance of Leishmania (Viannia) braziliensis to nitric oxide: correlation wi...
Souza, Anselmo; Giudice, Ângela; Pereira, Júlia M. B.; Guimarães, Luiz Henrique Santos; Jesus, Amélia Maria Ribeiro de; Moura, Tatiana Rodrigues deBACKGROUND: Nitric oxide (NO) produced in macrophages plays a pivotal role as a leishmanicidal agent. A previous study has demonstrated that 20% of the L. (V.) braziliensis isolated from initial cutaneous lesions of patients from the endemic area of Corte de Pedra, Bahia, Brazil, were NO resistant. Additionally, 5 to 11% of the patients did not respond to three or more antimony treatments" (refractory patients)...
BALB/c Mice Infected with Antimony Treatment Refractory Isolate of Leishmania b...
Costa, Diego Luis; Carregaro, Vanessa; Lima Júnior, Djalma S.; Silva, Neide M.; Milanezi, Cristiane M.; Cardoso, Cristina Ribeiro; Giudice, Ângela11 p.; Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2012-03-05T18:37:25Z No. of bitstreams: 1 journal.pntd.0000965.pdf: 1202285 bytes, checksum: 5c2616df5399151d5b3c2dfc7bdb6a25 (MD5); Made available in DSpace on 2012-03-05T18:37:25Z (GMT). No. of bitstreams: 1 journal.pntd.0000965.pdf: 1202285 bytes, checksum: 5c2616df5399151d5b3c2dfc7bdb6a25 (MD5) Previous issue date: 2011-02; Backg...