23 documents found, page 1 of 3

Novel Edaravone Derivatives as Neuroprotective Agents for the Treatment of ALS

Background: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease (ND) with limited treatment options [1]. Although with some drawbacks, Edaravone is one of the available drugs for ALS that targets oxidative stress (OS), a key factor in the pathophysiology of this disease [1]. Objective: This work aimed to evaluate the cytotoxic effects and neuroprotective potential of a new series of Edaravone der...

Bonding to Psychedelics: Synthesis of Molecularly Imprinted Polymers Targeting ...

The increasing interest in utilizing psychedelics for therapeutic purposes demands the development of tools capable of efficiently monitoring and accurately identifying these substances, thereby supporting medical interventions. 4-Bromo-2,5-dimethoxyphenethylamine (2C-B) has gained significant popularity as one of the most widely used psychedelic compounds in non-medical settings. In this study, we aimed to cre...

Effect of a Novel Hydroxybenzoic Acid Based Mitochondria Directed Antioxidant M...

Sperm cells are particularly vulnerable to reactive oxygen species (ROS), impairing their fertilizing ability. Our objective was to study the effect of a novel mitochondrial-directed antioxidant, AntiOxBEN2, on bovine sperm function. This antioxidant was added to the semen capacitation medium (CAP), during the swim-up process, and to the fertilization medium (FERT) during the co-incubation of matured oocytes an...

Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Weste...

Non-alcoholic fatty liver disease (NAFLD) is a health concern affecting 24% of the population worldwide. Although the pathophysiologic mechanisms underlying disease are not fully clarified, mitochondrial dysfunction and oxidative stress are key players in disease progression. Consequently, efforts to develop more efficient pharmacologic strategies targeting mitochondria for NAFLD prevention/treatment are underw...

A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondr...

Parkinson's Disease (PD) is a neurodegenerative disorder affecting more than 10 million people worldwide. Currently, PD has no cure and no early diagnostics methods exist. Mitochondrial dysfunction is presented in the early stages of PD, and it is considered an important pathophysiology component. We have previously developed mitochondria-targeted hydroxycinnamic acid derivatives, presenting antioxidant and iro...

Corrigendum to 'A mitochondria-targeted caffeic acid derivative reverts cellula...

Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidan...

Neurotransmitter depletion and mitochondrial dysfunction are among the multiple pathological events that lead to neurodegeneration. Following our previous studies related with the development of multitarget mitochondriotropic antioxidants, this study aims to evaluate whether the π-system extension on the chemical scaffolds of AntiOXCIN2 and AntiOXCIN3 affects their bioactivity and safety profiles. After the syn...

Biofilm control by ionic liquids

Ionic liquids (ILs) are remarkable chemical compounds with applications in many areas of modern science. They are increasingly recognized as promising compounds to fight microorganisms in both planktonic and biofilm states, contributing to reinvent the antimicrobial pipeline. Biofilm-related infections are particularly challenging given that the scientific community has not yet identified a reliable control str...

Electrochemical sensing of the thyroid hormone thyronamine (T0AM) via molecular...

Recent studies have shown that besides the well-known T3 (triiodothyronine) and T4 (thyroxine) there might be other important thyroid hormones, in particular T0AM (thyronamine) and T1AM (3-iodothyronamine). The absence of a large number of studies showing their precise importance might be explained by the limited number of analytical methodologies available. This work aims to show an electroanalytical alternati...

Hydroxybenzoic Acid Derivatives as Dual-Target Ligands: Mitochondriotropic Anti...

Alzheimer's disease (AD) is a multifactorial age-related disease associated with oxidative stress (OS) and impaired cholinergic transmission. Accordingly, targeting mitochondrial OS and restoring cholinergic transmission can be an effective therapeutic strategy toward AD. Herein, we report for the first time dual-target hydroxybenzoic acid (HBAc) derivatives acting as mitochondriotropic antioxidants and choline...