5 documents found, page 1 of 1
Suppression by allogeneic-specific regulatory T cells is dependent on the degre...
Bianchi, Joana; Vieira, Ana I. S.; Ligeiro, Dário; Azevedo, Rita I.; Lacerda, JoãoRegulatory T cell (Treg) infusion for graft-versus-host disease treatment has been increasingly investigated. However, polyclonal Treg may suppress the desired graft-versus-leukemia effect. Although allogeneic-specific (allo-specific) Treg may provide a more-targeted graft-versus-host disease treatment, there is the need to develop easily translatable expansion protocols and to better characterize their specifi...
Mesenchymal stromal cells induce regulatory T cells via epigenetic conversion o...
Azevedo, Rita I.; Minskaia, Ekaterina; Fernandes-Platzgummer, Ana; Vieira, Ana I. S.; da Silva, Cláudia Lobato; Cabral, Joaquim M.S.; Lacerda, JoãoRegulatory T cells (Treg) play a critical role in immune tolerance. The scarcity of Treg therapy clinical trials in humans has been largely due to the difficulty in obtaining sufficient Treg numbers. We performed a preclinical investigation on the potential of mesenchymal stromal cells (MSCs) to expand Treg in vitro to support future clinical trials. Human peripheral blood mononuclear cells from healthy donors ...
Naive and stem cell memory T cell subset recovery reveals opposing reconstituti...
Soares, Maria Vieira; Azevedo, Rita I.; Ferreira, Ines; Bucar, Sara; Ribeiro, Ana C.; Vieira, Ana I. S.; Pereira, Paulo N G; Ribeiro, Ruy M.The success of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in the treatment of hematological malignancies remains hampered by life-threatening chronic graft vs. host disease (cGVHD). Although multifactorial in nature, cGVHD has been associated with imbalances between effector and regulatory T cells (Treg). To further elucidate this issue, we performed a prospective analysis of patients underg...
Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeo...
Godinho-Silva, Cristina; Domingues, Rita G.; Rendas, Miguel; Raposo, Bruno; Ribeiro, Hélder; da Silva, Joaquim Alves; Vieira, Ana I. S.; Costa, Rui MGroup 3 innate lymphoid cells (ILC3s) are major regulators of inflammation, infection, microbiota composition and metabolism1. ILC3s and neuronal cells have been shown to interact at discrete mucosal locations to steer mucosal defence2,3. Nevertheless, it is unclear whether neuroimmune circuits operate at an organismal level, integrating extrinsic environmental signals to orchestrate ILC3 responses. Here we sho...
Molecular markers distinguishing T Cell subtypes with TSDR strand-bias methylation
Minskaia, Ekaterina; Saraiva, Bárbara C.; Soares, Maria Vieira; Azevedo, Rita I.; Ribeiro, Ruy M.; Kumar, Saumya; Vieira, Ana I. S.; Lacerda, JoãoHuman regulatory CD4+CD25+FOXP3+ T cells (Treg) play important roles in the maintenance of self-tolerance and immune homeostasis in various disease settings and are also involved in the suppression of effective immune responses. These cells are heterogeneous in phenotype and function, and the ability to reliably distinguish between various FOXP3-expressing subpopulations can affect the development of successful...