3 documents found, page 1 of 1
Different methods of synthesizing poly(glycerol sebacate) (PGS): a review
Godinho, Bruno; Gama, Nuno; Ferreira, ArturPoly(glycerol sebacate) (PGS) is a biodegradable elastomer that has attracted increasing attention as a potential material for applications in biological tissue engineering. The conventional method of synthesis, first described in 2002, is based on the polycondensation of glycerol and sebacic acid, but it is a time-consuming and energy-intensive process. In recent years, new approaches for producing PGS, PGS bl...
PU/lignocellulosic composites produced from recycled raw materials
Gama, Nuno; Godinho, Bruno; Barros-Timmons, Ana; Ferreira, ArturLignocellulosic composites are biodegradable, have low cost, neutrality to CO2 emission, easily processed, easily available and pause no health risks, therefore these materials have been the subject of an increase of interest. In addition, there is a continuous demand of materials obtained from renewable resources and waste recycling. In that sense, in this study polyurethane (PU) residues were mixed with resid...
The era of RNA interference medicines: the clinical landscape of synthetic gene...
Godinho, Bruno; Khvorova, AnastasiaABSTRACT - Therapeutic oligonucleotides, such as small interfering RNAs (siRNAs), provide a simple and effective tool to modulate the expression of any gene. siRNAs harness the RNA interference (RNAi) pathway to degrade disease-associated messenger RNAs (mRNAs). The inherent sequence specificity and potency of siRNAs makes them ideal drug candidates that are expected to transform drug development and our approa...