7 documents found, page 1 of 1
Loss of Hierarchical Imprinting Regulation at the Prader-Willi/Angelman Syndrom...
Pólvora-Brandão, D; Joaquim, M; Godinho, I; Aprile, D; Álvaro, AR; Onofre, I; Raposo, AC; Pereira de Almeida, L; Duarte, ST; da Rocha, STThe human chr15q11-q13 imprinted cluster is linked to several disorders, including Prader-Willi (PWS) and Angelman (AS) syndromes. Recently, disease modeling approaches based on induced pluripotent stem cells (iPSCs) have been used to study these syndromes. A concern regarding the use of these cells for imprinted disease modeling is the numerous imprinting defects found in many iPSCs. Here, by reprogramming ski...
CA-125 AUC as a predictor for epithelial ovarian cancer relapse
Mano, A; Falcão, A; Godinho, I; Santos, J; Leitão, F; Oliveira, CF; Caramona, MPURPOSE: The aim of the present work was to evaluate the usefulness of CA-125 normalized in time area under the curve (CA-125 AUC) to signalise epithelial ovarian cancer relapse. PATIENTS AND METHODS: Data from a hundred and eleven patients were submitted to two different approaches based on CA-125 AUC increase values to predict patient relapse. In Criterion A total CA-125 AUC normalized in time value (AUC(i)) ...
CA-125 AUC as a new prognostic factor for patients with ovarian cancer
Mano, A; Falcão, A; Godinho, I; Santos, J; Leitão, F; Oliveira, CF; Caramona, MOBJECTIVE: The aim of the present study was to investigate the usefulness of the CA-125 area under the curve (AUC) as a new kinetic parameter for predicting overall survival in patients with ovarian cancer. In addition, the relationship of CA-125 AUC with other prognostic factors of ovarian cancer was evaluated. METHODS: Ninety-two patients that underwent primary line chemotherapy within 4 months after submissi...
Valor prognóstico da expressão por imuno-histoquímica do c-erb-2: em doentes so...
Antunes, A; Silva, T; Godinho, I; Amaral, A; Oliveira, CFINTRODUCTION: The c-erb2 proto-oncogene is a member of the epidermal growth factor receptor family and has been associated with a more aggressive breast tumour biology and resistance to some types of treatments. AIMS: To evaluate the prognostic value of c-erb-2 receptor, from primary breast cancer on tamoxifen therapy. METHODS: We examined 66 paraffin-embedded sections from primary breast cancers. Patients were...
Carcinoma do Endométrio em Mulheres Jovens: caso clínico
Godinho, I; Sousa, R; Silva, T; Regateiro, FJ; Oliveira, CF; Oliveira, HM
Carcinoma do endométrio em mulheres jovens: a propósito de um caso clínico
Sousa, R; Silva, T; Carvalho, G; Cortesão, P; Franco, S; Godinho, I; Oliveira, CF
Randomised trial with bleomicin, ifosfamid and cisplatin as neoadjuvant chemoth...
Godinho, I; Gervásio, H; Moutinho, JC; Abraúl, E; Raimundo, D; Oliveira, CF