2 documents found, page 1 of 1
The Relevance of Thimet Oligopeptidase in the Regulation of Energy Metabolism a...
Gewehr, Mayara C. F.; Teixeira, Alexandre A. S.; Santos, Bruna A. C.; Biondo, Luana A.; Gozzo, Fabio C.; Cordibello, Amanda M.; Eichler, Rosangela A. S.Made available in DSpace on 2020-12-10T19:54:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-02-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Thimet oligopeptidase (EC 3.4.24.15; EP24.15; THOP1) is a potential therapeutic target, as it plays key biological functions in processing biologically functional peptides...
Mitochondrial DNA activates the nlrP3 inflammasome and predisposes to Type 1 di...
Carlos, Daniela; Costa, Frederico R. C.; Pereira, Camila A.; Rocha, Fernanda A.; Yaochite, Juliana N. U.; Oliveira, Gabriela G.; Carneiro, Fernando S.Although a correlation between polymorphisms of NOD-like receptor family-pyrin domain containing 3 (NLRP3) and predisposition to type 1 diabetes (T1D) has been identified, the potential function and activation of the NLRP3 inflammasome in T1D have not been clarified. The present study shows that non-obese diabetic mice exhibited increased NLRP3, and pro-IL-1β gene expression in pancreatic lymph nodes (PLNs). Si...