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Microtubule end conversion mediated by motors and diffusing proteins with no in...

Chakraborty, M; Tarasovetc, EV; Zaytsev, AV; Godzi, M; Figueiredo, AC; Ataullakhanov, FI; Grishchuk, EL

Accurate chromosome segregation relies on microtubule end conversion, the ill-understood ability of kinetochores to transit from lateral microtubule attachment to durable association with dynamic microtubule plus-ends. The molecular requirements for this conversion and the underlying biophysical mechanisms are elusive. We reconstituted end conversion in vitro using two kinetochore components: the plus end–direc...

Date: 2019   |   Origin: Repositório Aberto da Universidade do Porto
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