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Improving the identification of high-risk non-metastatic castration-resistant p...
Rosinha, Alina; Rabaça, Carlos; Calais, Fernando; Pinto, João Moreira; Barreira, João Vasco; Fernandes, Ricardo; Ramos, Rodrigo; Fialho, Ana CristinaNon-metastatic castration-resistant prostate cancer (nmCRPC) represents a challenging disease state in prostate cancer care. nmCRPC patients with a high risk of progression to metastatic disease who are identified by a prostate-specific antigen doubling time (PSADT) ≤10 months are eligible for treatment with the novel androgen receptor inhibitors (ARIs), shown to delay disease progression and extend survival. H...
Preventing Complications: Video Assisted Modified Inguinal Lymphadenectomy in S...
Pereira-Lourenço, Mário; Vieira-Brito, Duarte; Godinho, Ricardo; Peralta, Pedro; Conceição, Paulo; Rabaça, Carlos; Reis, Mário; Sismeiro, AmílcarModified inguinal lymphadenectomy allows for correct staging in most cases of penile cancer without palpable inguinal lymph nodes. Currently, it is possible to reproduce the classic surgical technique by video assisted surgery, with similar oncological results and smaller rate of complications. In this article, we report the case of a patient with penile cancer subjected to a total penectomy (pT3NxMx), where bi...
Cigarette Smoking Increases Oxidative Stress in Prostate Cancer Patients – A Pr...
Freitas, Mariana; Baldeiras, Inês; Proença, Teresa; Pascoal, Rui; Rabaça, Carlos; Valido, Frederico; Mota-Pinto, Anabela; Sarmento-Ribeiro, Ana BelaCigarette smoke is an oxidant, creating free radicals that are involved in carcinogenesis namely in Prostate Cancer (PC). However, a correlation between cigarette smoking and PC progression remains unclear. This study was directed to evaluate the correlation between cigarette smoking, Oxidative Stress (OS) and PC development and progression. The Total Antioxidant Status (TAS), Glutathione (GSH) and Malondialdeh...