9 documents found, page 1 of 1
SET domain-containing protein 4 (SETD4) is a newly identified cytosolic and nuc...
Faria, Jerusa Araújo Quintão Arantes; Corrêa, Natássia Caroline Resende; Andrade, Carolina de; Campos, Ana Carolina de AngelisCancer is comprised of a multitude of epigenetic abnormalities, including the global loss and regional gain of DNA methylation as well as alterations in histone methylation. Here, we characterize a new methyltransferase, SET domain-containing protein 4 (SETD4), which is involved in breast carcinogenesis. Quantitative real-time PCR (qPCR) showed elevated expression levels of SETD4 in several breast cancer cell l...
Attachment and proliferation of osteoblasts on lithium-hydroxyapatite composites
Schainberg, Ana Paula Muchon; Valério, Patrícia; Zonari, Alessandra; Oktar, Faik Nushek; Ozyegin, Luftie Sevgi; Graça, Manuel Pedro FernandesThe biocompatibility and bioactivity properties of hydroxyapatites (HAs) modified through lithium addition were investigated. Hydroxyapatites obtained from bovine bone were mixed with lithium carbonate (Li), in the proportions of 0.25, 0.50, 1.00, and 2.00%wt, and sintered at 900◦, 1000◦, 1100◦, 1200◦, and 1300◦C, creating LiHA samples. The osteoblast culture behavior was assessed in the presence of these LiHA ...
Combined use of Paracoccidioides brasiliensis recombinant rPb27 and rPb40 antig...
Fernandes, V. C.; Coitinho, Juliana Barbosa; Veloso, Juliana Márcia Ribeiro; Araújo, Stanley de Almeida; Pedroso, Enio Roberto PietraParacoccidioidomycosis (PCM) is one of themost important endemicmycoses in LatinAmerica; it's usually diagnosed by observation and/or isolation of the etiologic agent, Paracoccidioides brasiliensis, as well as by a variety of immunological methods, such as complement fixation and immunodiffusion. Although these approaches are useful, historically their sensitivity and specificity have often been compromised by ...
Down modulation of MHC surface molecules on B cells by suppressive immune compl...
Rezende, Simone Aparecida; Gollob, Kenneth John; Oliveira, Rodrigo Corrêa de; Goes, Alfredo Miranda deGranulomatous inflammation around parasite eggs is the prominent lesion in human schistosomiasis. Studies have suggested the involvement of a series of suppressive mechanisms in the control of this reaction, such as macrophages, cytokines, idiotipic interactions and immune complexes (IC). The studies examine the role of IC obtained from chronic intestinal schistosomiasis patients (ISP) in the reactivity of peri...
Role of immune complexes from pacients with different clinical forms of Schisto...
Rezende, Simone Aparecida; Lambertucci, José Roberto; Goes, Alfredo Miranda deSchistosomiasis is a disease whose pathology is strongly related to the granulomatous reaction formed around parasite eggs trapped in host tissues. Studies have shown that the chronic intestinal form (INT) of this infection is associated with a variety of immunoregulatory mechanisms which lead to a diminished granulomatous reaction. Using an in vitro model of granuloma reaction, we show that immune complexes (I...
Nitric oxide-mediated immune complex-induced prostaglandin E2 production by per...
Neves, Simone M. F.; Rezende, Simone Aparecida; Goes, Alfredo Miranda deGranuloma reaction around Schistosoma mansoni eggs is the prominent lesion in human schistosomiasis. Studies have suggested the involvement of a series of suppressive mechanisms in the control of this reaction. Using an in vitro model of granuloma formation, we have shown that immune complexes (IC) isolated from sera of chronic intestinal schistosomiasis patients were able to reduce granulomatous reaction devel...
Polymorphism analysis of the CTLA-4 gene in paracoccidioidomycosis patients
Lozano, Viviane Furlan; Lins, Tulio Cesar de Lima; Teixeira, Marcus de Melo; Vieira, Rodrigo G.; Blotta, Maria Heloisa de Souza LimaThe CTLA-4 protein is expressed in activated T cells and plays an essential role in the immune response through its regulatory effect on T cell activation. Polymorphisms of the CTLA-4 gene have been correlated with autoimmune, neoplastic and infectious illnesses. This work aimed to verify possible associations between single nucleotide polymorphisms (SNPs) in CTLA-4, -318C/T in the promoter and +49A/G in exon 1...
Schistosoma mansoni antigen-driven interleukin-10 production in infected asthma...
Oliveira, Sergio Costa; Pacífico, Lucila Grossi Gonçalves; Goes, Alfredo Miranda de; Oliveira, Ricardo Riccio; Cardoso, Luciana Santosp. 6; Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2012-01-07T01:43:22Z No. of bitstreams: 1 Schistosoma mansoni antigen-driven.pdf: 217763 bytes, checksum: e119d6db58de471e43ff1ec4b42986b5 (MD5); Made available in DSpace on 2012-01-07T01:43:22Z (GMT). No. of bitstreams: 1 Schistosoma mansoni antigen-driven.pdf: 217763 bytes, checksum: e119d6db58de471e43ff1ec4b42986b5 (MD5) Previous i...
Experimental Corynebacterium pseudotuberculosis primary infection in goats: kin...
Paule, Bruno Jean Adrien; Azevedo, Vasco Ariston de Carvalho; Regis, Lia Fernandes; Bahia, Robson Cerqueira; Carminati, Renato; Vale, Vera Lucia Costap.129–139; Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2012-01-25T16:28:44Z No. of bitstreams: 1 S0165242703001466-main.pdf: 235186 bytes, checksum: 731a4741820d0d959992597c856df2fd (MD5); Made available in DSpace on 2012-01-25T16:28:45Z (GMT). No. of bitstreams: 1 S0165242703001466-main.pdf: 235186 bytes, checksum: 731a4741820d0d959992597c856df2fd (MD5) Previous issue date: 2003; Co...