8 documents found, page 1 of 1
The effect of high concentration of zoledronic acid on tooth induced movement a...
Sousa, Fátima Regina Nunes de; Ferreira, Vanessa Costa de Sousa; Martins, Conceição da Silva; Dantas, Hugo Victor; Sousa, Frederico Barbosa deZoledronic acid (ZA) is often prescribed for osteoporosis or resorptive metabolic bone disease. This study aims to evaluate the effect of ZA on orthodontic tooth movement (OTM) and root and bone resorption and its repercussion on root, periodontal ligament and alveolar bone tissues. The experimental group consisted of 72 Wistar rats divided in four subgroups: Naive, Saline and Zoledronic Acid groups at the conc...
Loss of Dkk-1 in osteocytes mitigates alveolar bone loss in mice with periodont...
Goes, Paula; Dutra, Caio; Lösser, Lennart; Hofbauer, Lorenz C.; Rauner, Martina; Thiele, SylviaBackground: Periodontitis is a highly prevalent infection-triggered inflammatory disease that results in bone loss. Inflammation causes bone resorption by osteoclasts, and also by suppression of bone formation via increase of Dickkopf-1 (Dkk-1), an inhibitor of Wnt signaling. Here, we tested the hypothesis that osteocytic Dkk-1 is a key factor in the pathogenesis of periodontitis-induced alveolar bone loss (ABL...
Stemodia maritima L. extract decreases inflammation, oxidative stress, and alve...
Teixeira, Alrieta H.; Freire, Jordânia M. de Oliveira; Sousa, Luzia H. T. de; Parente, Antônia T.; Sousa, Nayara A. de; Arriaga, Angela M. C.Periodontitis is very prevalent worldwide and is one of the major causes of tooth loss in adults. About 80% of the worldwide population use medicinal plants for their health care. Stemodia maritima L. (S. maritima) antioxidant and antimicrobial effects in vitro as well as anti-inflammatory properties. Herein, the potential therapeutic effect of S. maritima was assessed in rats subjected to experimental periodon...
The effect of Calendula officinalis on oxidative stress and bone loss in experi...
Lima, Mariana dos Reis; Lopes, Amanda P.; Martins, Conceição; Brito, Gerly A. C.; Carneiro, Virgínia C.; Goes, PaulaPeriodontitis is associated with reduced antioxidant capacity and increased oxidative damage. Oxidative stress induces inflammation and bone loss contributing to the pathological progression of periodontal disease. Calendula officinalis (CLO) has demonstrated anti-inflammatory and anti-oxidant activities. Therefore, the aim of this study was to evaluate the effect of CLO on oxidative stress and bone loss in rat...
Anti-inflammatory and anti-resorptive effects of atorvastatin on alveolar bone ...
Goes, Paula; Lima, Neiberg Alcântara; Rodrigues, José Ariévilo Gurgel; Benevides, Norma Maria Barros; Brito, Gerly Anne Castro; Lima, VilmaThe aim of this study was to evaluate the anti-inflammatory and anti-resorptive effect of atorvastatin (ATV) in an experimental alveolar bone loss (ABL) model. Wistar rats were subjected to ligature placement around the maxillary second molar for 11 days. The animals received 0.9% saline (2 mL/kg) or ATV (0.3, 3 or 27 mg/kg) daily by gavage. ABL was evaluated by resorption area and histopathological analysis. S...
Efeito da raspagem e alisamento radicular em pacientes com artrite reumatoide :...
Goes, Paula; Coelho, Anderson Chagas; Oliveira, Camila CarvalhoIntroduction: Periodontal disease (PD) is an infectious inflammatory disease that causes an exaggerated immune-inflammatory response, culminating in the loss of tooth supporting tissues. PD can relate to other systemic diseases, including rheumatoid arthritis (RA), which is an autoimmune chronic inflammatory disease characterized by the destruction of joints and leading to motor impairment. These two diseases h...
Effect of alendronate on bone-specific alkaline phosphatase on periodontal bone...
Goes, Paula; Melo, Iracema M.; Dutra, Caio S.; Lima, Ana Patrícia S.; Lima, VilmaObjective: The study aims to evaluate the effect of alendronate (ALD) on bone-specific alkaline phosphatase (BALP) serum levels on periodontal bone loss in Wistar rats. Design: Periodontitis was induced by ligature around the upper second molar in 36 male Wistar rats ( 200 g). Groups of six animals received 0.9% saline (SAL) or ALD (0.01; 0.05; 0.25 mg kg 1, s.c.), over 11 days; then they were sacrificed and th...
Prevalência de acidentes ocupacionais e perfil de vacinação contra Hepatite B e...
Andrade Neto, Epitácio Pessoa de; Dutra, Caio de Santiago; Lima, Vilma; Goes, PaulaObjetivo: Determinar a prevalência de acidentes ocupacionais e situação vacinal contra Hepatite B entre acadêmicos e profissionais da área de Odontologia. Materiais e Métodos: Este estudo piloto, de caráter descritivo, utilizou durante a coleta de dados um questionário aplicado composto por itens de identificação, características do acidente e conduta frente à exposição. A amostra foi constituída de acadêmicos ...