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Mitch a rapidly evolving component of the Ndc80 kinetochore complex required fo...
Williams, B; Leung, G; Maiato, H; Wong, A; Li, Z; Williams, E; Kirkpatrick, C; Aquadro, CF; Rieder, CL; Goldberg, MLWe identified an essential kinetochore protein, Mitch, from a genetic screen in D. melanogaster. Mitch localizes to the kinetochore, and its targeting is independent of microtubules (MTs) and several other known kinetochore components. Animals carrying mutations in mitch die as late third-instar larvae; mitotic neuroblasts in larval brains exhibit high levels of aneuploidy. Analysis of fixed D. melanogaster bra...
Date: 2007
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Origin: Repositório Aberto da Universidade do Porto