4 documents found, page 1 of 1
Fibrin biopolymer as scaffold candidate to treat bone defects in rats
Cassaro,Claudia Vilalva; Justulin Jr.,Luis Antonio; Lima,Patrícia Rodrigues de; Golim,Marjorie de Assis; Biscola,Natália PerussiABSTRACT Background: Bone tissue repair remains a challenge in tissue engineering. Currently, new materials are being applied and often integrated with live cells and biological scaffolds. The fibrin biopolymer (FBP) proposed in this study has hemostatic, sealant, adhesive, scaffolding and drug-delivery properties. The regenerative potential of an association of FBP, biphasic calcium phosphate (BCP) and mesench...
Influence of the inflammatory response on treatment of hepatitis C with triple ...
Winckler,Fernanda Cristina; Braz,Aline Marcia Marques; Silva,Vanessa Nogueira da; Golim,Marjorie de Assis; Andrade,Vanessa Gutierrez deAbstract INTRODUCTION: Chronic hepatitis C is a leading cause of liver disease. Infection triggers an immediate immune response in the host that is mediated by humoral/cellular mechanisms. T cells respond to infection via secretion of cytokines, which inhibit or stimulate one another, leading to cytokine imbalance and ultimately affecting treatment. Studies using interferon (IFN) and ribavirin (RBV) showed that...
Cyclosporine A attenuates apoptosis and necrosis after ischemia-reperfusion-ind...
Lemos Neto,Sylvio Valença de; Vianna,Isabela Galvão; Castiglia,Yara Marcondes Machado; Golim,Marjorie de Assis; Souza,Aparecida Vitória Gonçalves deAbstract Purpose: To investigate the effects of cyclosporine A on renal ischemia-reperfusion injury during transient hyperglycemia in rats. Methods: In a model of ischemia-reperfusion-induced renal injury and transiently induced hyperglycemia by intraperitoneal injection of glucose, 2.5 g.kg-1, Wistar rats were anesthetized with either isoflurane or propofol and received intravenous cyclosporine A, 5 mg.kg-1, f...
Does propofol and isoflurane protect the kidney against ischemia/reperfusion in...
Carraretto,Antônio Roberto; Vianna Filho,Pedro Thadeu Galvão; Castiglia,Yara Marcondes Machado; Golim,Marjorie de AssisPURPOSE: To study the effect of isoflurane (Iso) or propofol (Prop) anesthesia on renal ischemia/reperfusion injury (IRI) during transient hyperglycemia. METHODS: Thirty six rats were randomly assigned into six groups of six animals each: PHS (Sham-Prop=1mg.kg-1.min-1 + Hyperglycemia=2.5g.kg-1 of glucose solution administered intraperitoneally); HIS (Sham-Iso + Hyperglycemia); PHI (Prop + Hyperglycemia + Ischem...