14 documents found, page 1 of 2
Immunochemotherapy in american cutaneous leishmaniasis : immunological aspects ...
Toledo, Vicente de Paulo Coelho Peixoto de; Mayrink, Wilson; Gollob, Kenneth John; Oliveira, Milton Adriano Pelli de; Costa, Carlos Alberto daIn this study, we evaluated the immune response of patients suffering from cutaneous leishmaniasis treated with two distinct protocols. One group was treated with conventional chemotherapy using pentavalent antimonium salts and the other with immunochemotherapy where a vaccine against cutaneous leishmaniasis was combined with the antimonium salt. Our results show that, although no differences were observed in t...
Immunoregulatory and effector activities in human cutaneous and mucosal Leishma...
Dutra, Walderez Ornelas; Faria, Daniela Rodrigues de; Machado, Paulo Roberto Lima; Guimarães, Luiz Henrique; Schriefer, Nicolaus Albert BorgesTexto completo: acesso restrito. p. 430–436; Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-04-15T13:32:05Z No. of bitstreams: 1 Walderez O. Dutra.pdf: 210259 bytes, checksum: 6b92f994917e2a0c10b483f278aeb54a (MD5); Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-11-04T15:21:01Z (GMT) No. of bitstreams: 1 Walderez O. Dutra.pdf: 210259 bytes, checksum: 6b92f99491...
Oxidant generation by single infected monocytes after short-term fluorescence l...
Chang, Haeok K.; Thalhofer, Colin; Duerkop, Breck A.; Mehling, Joanna S.; Verma, Shilpi; Gollob, Kenneth John; Almeida, Roque Pacheco deTexto completo: acesso restrito. p. 1017–1024; Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-03-11T15:14:47Z No. of bitstreams: 1 10.1128IAI.00914-06.pdf: 554649 bytes, checksum: e4ffaf2b2ca32eca83ae35e61b28e6e0 (MD5); Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-04-09T13:04:35Z (GMT) No. of bitstreams: 1 10.1128IAI.00914-06.pdf: 554649 bytes, checksum: e4ffaf2b...
Helminthic Infection Down-Regulates Type 1 Immune Responses in Human T Cell Lym...
Santos, Silvane Maria Braga; Rodrigues Junior, Waldyr; Muniz, André Luís Nunes; Basílio, Vanessa; Neva, Franklin A.; Dutra, Walderez OrnelasTexto completo: acesso restrito. p. 612-618.; Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-11-29T11:17:26Z No. of bitstreams: 1 Silvane B. Santos.pdf: 435684 bytes, checksum: 61d491af11b14d5ca3b7008acbc433af (MD5); Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-01-07T13:33:33Z (GMT) No. of bitstreams: 1 Silvane B. Santos.pdf: 435684 bytes, checksum: 61d491af1...
Up-regulation of Th1-type responses in mucosal leishmaniasis patients
Bacellar, Olívia; Lessa, Hélio; Schriefer, Albert; Machado, Paulo Roberto Lima; Jesus, Amélia Maria Ribeiro de; Dutra, Walderez OrnelasThe cytokine profile produced by peripheral blood mononuclear cells (PBMC) in response to leishmania antigens and the ability of interleukin-10 (IL-10) and transforming growth factor β (TGF-β) to modulate the immune response were evaluated in 21 mucosal leishmaniasis patients. Patients with mucosal disease exhibited increased gamma interferon (IFN-γ) and tumor necrosis factor alpha (TNF-α) secretion and decreas...
Unequivocal identification of subpopulations in putative multiclonal Trypanosom...
Valadares, Helder Magno Silva; Pimenta, Juliana Ramos; Segatto, Marcela; Veloso, Vanja Maria; Gomes, Mônica Lúcia; Chiari, Egler; Gollob, Kenneth JohnTrypanosoma cruzi, the etiological agent of Chagas disease, is a polymorphic species. Evidence suggests that the majority of the T. cruzi populations isolated from afflicted humans, reservoir animals, or vectors are multiclonal. However, the extent and the complexity of multiclonality remain to be established, since aneuploidy cannot be excluded and current conventional cloning methods cannot identify all the r...
Decreased in situ expression of interleukin-10 receptor is correlated with the ...
Faria, Daniela Rodrigues de; Gollob, Kenneth John; Barbosa Júnior, José; Schriefer, Nicolaus Albert Borges; Machado, Paulo Roberto Lima; Lessa, HélioHuman infection with Leishmania braziliensis can lead to cutaneous leishmaniasis (CL) or mucosal leishmaniasis (ML). We hypothesize that the intense tissue destruction observed in ML is a consequence of an uncontrolled exacerbated inflammatory immune response, with cytotoxic activity. For the first time, this work identifies the cellular sources of inflammatory and antiinflammatory cytokines, the expression of ...
Down modulation of MHC surface molecules on B cells by suppressive immune compl...
Rezende, Simone Aparecida; Gollob, Kenneth John; Oliveira, Rodrigo Corrêa de; Goes, Alfredo Miranda deGranulomatous inflammation around parasite eggs is the prominent lesion in human schistosomiasis. Studies have suggested the involvement of a series of suppressive mechanisms in the control of this reaction, such as macrophages, cytokines, idiotipic interactions and immune complexes (IC). The studies examine the role of IC obtained from chronic intestinal schistosomiasis patients (ISP) in the reactivity of peri...
IgG isotype profile is correlated with cardiomegaly in Beagle dogs infected wit...
Guedes, Paulo Marcos da Matta; Veloso, Vanja Maria; Gollob, Kenneth John; Afonso, Luís Carlos Crocco; Caldas, Ivo Santana; Vianna, PriscilaA systematic study following infection by various strains of the protozoan parasite, Trypanosoma cruzi, and the simultaneous monitoring of the humoral immune response together with the elicited cellular response, could add greatly to our understanding of differences between strains of this important human pathogen. In that sense, acute and chronic infections with distinct T. cruzi strains (Y, Berenice-78 and AB...
Low levels of vasoactive intestinal peptide are associated with Chagas disease ...
Corrêa, Marielle Valério; Rocha, Manoel Otávio da Costa; Sousa, Giovane Rodrigo de; Nunes, Maria do Carmo Pereira; Gollob, Kenneth JohnThe interconnection between immune and neuroendocrine systems influences regulation of inflammatory responses. The possible relevance that this integrative response may have during the course of Chagas disease remains poorly characterized. In this context, our study was designed to determine the expression of vasoactive intestinal peptide (VIP), a neuropeptide with anti-inflammatory properties, in blood from th...